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| | 3,5-Dimethylpyrazole Basic information |
| | 3,5-Dimethylpyrazole Chemical Properties |
| Melting point | 105-108 °C (lit.) | | Boiling point | 218 °C (lit.) | | density | 0,884 g/cm3 | | refractive index | 1.4739 (estimate) | | Fp | 210°C | | storage temp. | Sealed in dry,Room Temperature | | solubility | methanol: 0.1 g/mL, clear | | pka | 15.12±0.10(Predicted) | | form | Crystalline Powder or Crystals | | color | White to almost white | | PH | 6.7 (14g/l, H2O, 20℃) | | Water Solubility | Soluble in water, methanol 0.1 g/mL. | | BRN | 106325 | | InChIKey | SDXAWLJRERMRKF-UHFFFAOYSA-N | | LogP | 1.010 | | CAS DataBase Reference | 67-51-6(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Pyrazole, 3,5-dimethyl-(67-51-6) | | EPA Substance Registry System | 3,5-Dimethylpyrazole (67-51-6) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | UQ6477600 | | TSCA | Yes | | HazardClass | IRRITANT | | HS Code | 29331990 |
| | 3,5-Dimethylpyrazole Usage And Synthesis |
| Chemical Properties | White crystal powder | | Uses | Common reagent for the preparation of pyrazolato ligated complexes.1,2 Also used to prepare N-1-substituted derivatives having antibacterial activity.3 | | Uses | 3,5-Dimethylpyrazole is used as intermediate for the manufacture of organic dyestuffs and photochemicals. Product Data Sheet | | Uses | 3,5-Dimethylpyrazole his a catalyst in the sulfonation of acetic anhydride to sulfoacetic acid and methanedisulfonic acid. 3,5-Dimethylpyrazole has been used in the synthesis of bipyrazolic tripodal derivatives with in vitro antitumor, antifungal and antibacterial activities. | | Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 19, p. 373, 1982 DOI: 10.1002/jhet.5570190231
Organic Syntheses, Coll. Vol. 4, p. 351, 1963 | | Purification Methods | Crystallise it from cyclohexane or water. [Barszez et al. J Chem Soc, Dalton Trans 2025 1986, Beilstein 23/5 V 110.] |
| | 3,5-Dimethylpyrazole Preparation Products And Raw materials |
| Raw materials | 1H-Pyrazole, 3,5-dimethyl-1-[2-[(4-methylphenyl)sulfonyl]ethyl]--->1-(4-methoxyphenyl)-3,5-dimethyl-1H-Pyrazole-->ETHYL 3-AMINO-4,6-DIMETHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE-->1-ALLYL-3 5-DIMETHYLPYRAZOLE 96-->1-CYANOACETYL-3,5-DIMETHYLPYRAZOLE-->4-Bromo-3,5-dimethylpyrazole-->Semicarbazide hydrochloride-->Hydrazine hydrate-->2,3-Pentanedione | | Preparation Products | 4-Bromo-1,3,5-trimethyl-1H-pyrazole-->(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)METHYLAMINE-->1,3,5-Trimethylpyrazole-->1,3,5-Trimethyl-1H-pyrazole-4-carboxaldehyde-->3,5-PYRAZOLEDICARBOXYLIC ACID-->1,3,5-TRIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID-->1H-Pyrazole-4-carbonyl chloride, 1,3,5-trimethyl- (9CI)-->1,4-Dioxaspiro[4.5]decan-8-one-->DIETHYL 3,5-PYRAZOLEDICARBOXYLATE-->3,5-DIMETHYLPYRAZOLE-1-METHANOL-->4-amino-3,5-dimethyl-pyrazol-->Benzenesulfonic acid, 3-[2-[4-[2-(3,5-dimethyl-1H-pyrazol-4-yl)diazenyl]-2,5-dimethoxyphenyl]diazenyl]-, sodium salt (1:1) |
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