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| | HARRINGTONINE Basic information |
| | HARRINGTONINE Chemical Properties |
| Melting point | 73～75℃ | | Boiling point | 679.4±55.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 11.62±0.29(Predicted) |
| RIDADR | 1544 | | HazardClass | 6.1(a) | | PackingGroup | II |
| | HARRINGTONINE Usage And Synthesis |
| Description | The full structure of harringtonine has now been established from a study of the
hydrolysis products of this base. | | Description | Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations. It immobilizes ribosomes immediately after the initiation of translation. While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia. The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation. | | Chemical Properties | White Solid | | Uses | specific anti-leukemia drug | | Uses | A natural product with significant antitumor activities. | | Definition | ChEBI: Harringtonine is an alkaloid. | | References | Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972)
Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973) |
| | HARRINGTONINE Preparation Products And Raw materials |
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