4-Methylbenzyl alcohol

4-Methylbenzyl alcohol Basic information
Product Name:4-Methylbenzyl alcohol
Synonyms:p-Methylbenzylalkohol;p-Tolyl-methanol;p-Tolymethanol;4-Metylbenzyl Alcohol;Methylbenzylalcohol,97%;PARA-METHYLBENZYLALCOHOL;4-Methylbenzylalkohol;4-Methylbenzylalcohol,99%
CAS:589-18-4
MF:C8H10O
MW:122.16
EINECS:209-639-1
Product Categories:Benzhydrols, Benzyl & Special Alcohols;Alcohols;C7 to C8;Oxygen Compounds;bc0001
Mol File:589-18-4.mol
4-Methylbenzyl alcohol Structure
4-Methylbenzyl alcohol Chemical Properties
Melting point 59-61 °C(lit.)
Boiling point 217 °C(lit.)
density 0,98 g/cm3
vapor pressure 1.6Pa at 25℃
refractive index 1.5265 (estimate)
FEMA 4624 | 4-METHYLBENZYL ALCOHOL
Fp 116-118°C/20mm
storage temp. Sealed in dry,Room Temperature
form Crystalline Mass, Needles, or Crystals
pka14.49±0.10(Predicted)
color White
Odormild floral
Odor Typefloral
Water Solubility Soluble in methanol, ether and ethanol. Slightly soluble in water.
JECFA Number2065
BRN 1856550
LogP1.67 at 20℃
CAS DataBase Reference589-18-4(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenemethanol, 4-methyl-(589-18-4)
EPA Substance Registry System4-Methylbenzenemethanol (589-18-4)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 2
RTECS DO9370000
TSCA Yes
HS Code 29062990
Hazardous Substances Data589-18-4(Hazardous Substances Data)
MSDS Information
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4-Methylbenzyl alcohol English
SigmaAldrich English
ACROS English
ALFA English
4-Methylbenzyl alcohol Usage And Synthesis
Chemical Propertieswhite crystalline mass, needles or crystals
UsesPerfumery, flavoring dyes, laboratory reagent.
Uses4-Methylbenzyl alcohol is used in fragrances, flavoring and as a laboratory reagent. It is also used as a raw material for the preparation of polycarbonates and 4-methyl-benzaldehyde.
Production Methodsp-Tolyl alcohol is commercially prepared by reducing p-tolyl aldehyde. It is used mainly in fragrances, and the major route of exposure is likely to be dermal contact.
DefinitionChEBI: A methylbenzyl alcohol in which the methyl substituent is para to the hydroxymethyl group.
Synthesis Reference(s)The Journal of Organic Chemistry, 52, p. 946, 1987 DOI: 10.1021/jo00381a047
General DescriptionNeedles or off-white crystalline powder.
Air & Water ReactionsSlightly soluble in water.
Reactivity Profile4-Methylbenzyl alcohol can react with acids, acid chlorides, acid anhydrides and oxidizing agents.
Health HazardACUTE/CHRONIC HAZARDS: When heated to decomposition 4-Methylbenzyl alcohol emits acrid smoke and toxic fumes of carbon monoxide and carbon dioxide.
Fire HazardFlash point data for 4-Methylbenzyl alcohol are not available. 4-Methylbenzyl alcohol is probably combustible.
Flammability and ExplosibilityNotclassified
Purification MethodsCrystallise the alcohol from pet ether (b 80-100o, 1g/mL), Et2O, pentane or H2O (m 61-62.1o). It can also be distilled in a vacuum. [Beilstein 6 H 498, 6 I 248, 6 II 469, 6 III 1779.]
4-Methylbenzyl alcohol Preparation Products And Raw materials
Preparation ProductsBenzenamine, N-butyl-N,4-dimethyl--->2,5-Dimethylphenylacetic acid-->Methyl 4-methylbenzoate-->4,N-DIMETHYL-N-METHOXYBENZAMIDE-->2,4,6-trip-tolyl-1,3,5-triazine-->P-BUTOXYTOLUENE-->4-Methylbenzyl acetate-->5-Bromo-7-nitroindoline-->2-FLUORO-6-(4-METHYLBENZYLOXY)BENZONITRILE-->2,5-Dimethylphenol-->2'-CHLORO-3-(4-METHYLPHENYL)PROPIOPHENONE
METHYLBENZYL ALCOHOL(SG) (s)-(-)-2-bromo-α-methylbenzyl alcohol,(S)-2-Bromo-alpha-methylbenzyl alcohol, 95% (98% e.e.) (R)-3-Bromo-alpha-methylbenzyl alcohol, 95% (98% E.E.)% Methyl cyclopentenolone 3-HYDROXY-4-METHYLBENZYL ALCOHOL à-cyclopropyl-à-methylbenzyl alcohol 3-(Trifluoromethyl)benzyl alcohol 2,3-DIFLUORO-4-METHYLBENZYL ALCOHOL (S)-4-Fluoro-α-methylbenzyl alcohol 4-FLUORO-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL 3,4-DIMETHOXY-2-METHYLBENZYL ALCOHOL (3,4-Dimethylphenyl)methanol 3,5-Dihydroxy-α-[p-hydroxy-α-methylphenethylamino]methylbenzyl alcohol -METHYL-2-TRIFLUOROMETHYLBENZYL ALCOHOL 2,3,5,6-tetrafluoro-4-methyl-Benzenemethanol Etilefrine hydrochloride (R)-4-Bromo-alpha-methylbenzyl alcohol, 95% (98% e.e.) 2,3,5,6-TETRAFLUORO-4-METHYLBENZYL ALCOHOL

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