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| | L-Isoleucine Basic information |
| | L-Isoleucine Chemical Properties |
| Melting point | 288 °C (dec.) (lit.) | | alpha | 41 º (c=4, 6N HCl) | | Boiling point | 225.8±23.0 °C(Predicted) | | density | 1.2930 (estimate) | | FEMA | 4675 | L-ISOLEUCINE | | refractive index | 40.5 ° (C=4, 6mol/L HCl) | | Fp | 168-170°C | | storage temp. | Store below +30°C. | | solubility | 1 M HCl: 50 mg/mL | | pka | 2.32, 9.76(at 25℃) | | form | powder | | color | White to Off-white | | PH | 5.5-6.5 (40g/l, H2O, 20℃) | | Odor | odorless | | optical activity | [α]20/D +41.0±1°, c = 5% in 6 M HCl | | Water Solubility | 41.2 g/L (50 ºC) | | λmax | λ: 260 nm Amax: 0.07
λ: 280 nm Amax: 0.05 | | Sublimation | 168-170 ºC | | Merck | 14,5179 | | JECFA Number | 2118 | | BRN | 1721792 | | InChIKey | AGPKZVBTJJNPAG-WHFBIAKZSA-N | | LogP | 0.80 | | CAS DataBase Reference | 73-32-5(CAS DataBase Reference) | | NIST Chemistry Reference | Isoleucine(73-32-5) | | EPA Substance Registry System | L-Isoleucine (73-32-5) |
| | L-Isoleucine Usage And Synthesis |
| Description | Crystalline leaflets or a white, crystalline powder having a bitter
taste. It is soluble in 25 parts of water, slightly soluble in hot
alcohol, and soluble in diluted mineral acids and in alkaline solutions. It sublimes at between 168°C and 170°C, and melts with
decomposition at about 284°C. The pH of a 1 in 100 solution is
between 5.5 and 7.0.
Absolute: The absolute is prepared by alcoholic extraction of the
concrete in approximately 55 to 60% yields. The absolute consists
of a semisolid, olive-green mass with a characteristic ambergris
odor.
Resinoid and Resin Absolute: The resinoid consists of the hydro carbon extract of the crude resin. The resin absolute consists of
the alcoholic extract of the crude labdanum resin. Since this prod uct is a semisolid, nonpourable mass, a high-boiling, odorless
solvent may be added prior to evaporation of the alcohol to prepare
a pourable liquid. | | Chemical Properties | White crystalline powder | | Uses | L-Isoleucine, also known as Isoleucine, is an amino acid that is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
L-Isoleucine is one of the essential amino acids that cannot be made by the body and is known for its ability to help endurance and assist in the repair and rebuilding of muscle. This amino acid is important to body builders as it helps boost energy and helps the body recover from training.
L-Isoleucine is also classified as a branched-chain amino acid (BCAA). There are three branched-chain amino acids in the body, with the others being L-Valine, and L-Leucine, and all of them help promote muscle recovery after exercise. Isoleucine is actually broken down for energy within the muscle tissue.
| | Uses | L-Isoleucine acts as an essential amino acid in human. It is used as a flavoring agent and nutritional supplement for foods. It is also used as an antipsychotic. It is employed as a component of proteins. Further, it stimulates immune function and promotes secretion of several hormones. In addition to this, it is used for hemoglobin formation and regulating blood sugar and energy levels. | | Uses | L-Isoleucine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique. | | Definition | ChEBI: The L-enantiomer of isoleucine. | | Biochem/physiol Actions | L-Isoleucine is an isomer of L-leucine and is an essential amino acid. It is synthesized from threonine and is a branched-chain hydrophobic amino acid. | | Purification Methods | Crystallise L-isoleucine from H2O by addition of 4 volumes of EtOH or from aqueous MeOH. It sublimes at 170-181o/0.3mm with 99.7% recovery, unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 1 p 183-191, Vol 3 pp 2043-2073 1961, Huffman & Ingersoll J Am Chem Soc 73 3366 1951, Beilstein 4 IV 2775.] |
| | L-Isoleucine Preparation Products And Raw materials |
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