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| | NICLOFOLAN Basic information |
| Product Name: | NICLOFOLAN | | Synonyms: | NICLOFOLAN;Niclofoian;1'-biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-(;3,3'-dichloro-5,5'-dinitro-o,o'-biphenol;4,4'-dichloro-6,6'-dinitro-o,o'-biphenol;5,5'-dichloro-2,2'-dihydroxy-3,3'-dinitrobiphenyl;5,5'-dichloro-3,3'-dinitro(1,1'-biphenyl)-2,2'-diol;menichlopholan | | CAS: | 10331-57-4 | | MF: | C12H6Cl2N2O6 | | MW: | 345.09 | | EINECS: | 233-720-0 | | Product Categories: | API | | Mol File: | 10331-57-4.mol |  |
| | NICLOFOLAN Chemical Properties |
| Boiling point | 251.5°C (rough estimate) | | density | 1.8594 (rough estimate) | | refractive index | 1.7350 (estimate) | | pka | 4.34±0.40(Predicted) | | EPA Substance Registry System | Niclofolan (10331-57-4) |
| Toxicity | bird - wild,LD50,oral,13mg/kg (13mg/kg),Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. |
| | NICLOFOLAN Usage And Synthesis |
| Chemical Properties | Orange-yellow crystalline powder. Melting point 178-182 ℃. Soluble in acetone, glacial acetic acid and sodium hydroxide solution, slightly soluble in water and ethanol. | | Uses | Niclofolan can be used as deworming drug and anti-creep drug. It is used for prevention and treatment of hepatic chioniasis of cattle and sheep. | | Definition | ChEBI: Niclofolan is a polychlorobiphenyl. | | Synthesis | Niclofolan is obtained by nitration of 5,5 '-dichloro-2, 2' dihydroxybiphenyl. The nitration was carried out in acetic acid at a temperature not exceeding 20℃. Then activated carbon was added for reflux decolorization for 1h. The filter was pumped with a nitrate filter rod. The filtrate was cooled below 15℃ and crystallized. Dinitrochlorophenol was obtained by filtration, washing with acetic acid and drying. The yield is 60%. |
| | NICLOFOLAN Preparation Products And Raw materials |
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