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2-Hydroxy-N-(4-hydroxyphenyl)-benzamide

2-Hydroxy-N-(4-hydroxyphenyl)-benzamide Basic information
Product Name:2-Hydroxy-N-(4-hydroxyphenyl)-benzamide
Synonyms:LOIRD;2-hydroxy-n-(4-hydroxyphenyl)-benzamide;2-hydroxy-n-(4-hydroxyphenyl)-benzamid;4’-hydroxy-salicylanilid;4’-hydroxysalicylanilide;4-Hydroxysalicylanilide;auxobil;OSALMID
CAS:526-18-1
MF:C13H11NO3
MW:229.23
EINECS:208-385-9
Product Categories:
Mol File:526-18-1.mol
2-Hydroxy-N-(4-hydroxyphenyl)-benzamide Structure
2-Hydroxy-N-(4-hydroxyphenyl)-benzamide Chemical Properties
Melting point 179°
Boiling point 371.13°C (rough estimate)
density 1.2084 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5500 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO : ≥ 28 mg/mL (122.15 mM)
pka8.40±0.30(Predicted)
Water Solubility 916mg/L at 25℃
LogP2.47 at 25℃
CAS DataBase Reference526-18-1(CAS DataBase Reference)
EPA Substance Registry SystemOsalmid (526-18-1)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38-42/43
Safety Statements 26-36/37
ToxicityLD50 oral in rat: 6702mg/kg
MSDS Information
2-Hydroxy-N-(4-hydroxyphenyl)-benzamide Usage And Synthesis
DefinitionChEBI: Osalmid is an organic molecular entity.
Biochem/physiol ActionsOsalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown.
2-Hydroxy-N-(4-hydroxyphenyl)-benzamide Preparation Products And Raw materials
Raw materials4-Aminophenol-->Phenyl salicylate-->Salicylic acid-->Salicylamide
NAPHTHOL AS-LT AURORA 383 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide 4'-ethoxysalicylanilide 3-Hydroxy-4'-methoxy-2-naphthanilide 2-Hydroxy-N-(4-methoxyphenyl)-11H-benzo[a]carbazole-3-carboxamide 2-[(4-METHOXYANILINO)CARBONYL]PHENYL-N,N-DIMETHYLSULFAMATE NAPTHOL AS-SG 5-chloro-2-hydroxy-N-(4-hydroxyphenyl)benzamide N,N-DIMETHYL(2-([4-(TRIFLUOROMETHOXY)ANILINO]CARBONYL)PHENYL)SULFAMATE AURORA 3975 AURORA 3538 AURORA 676 N-(4-HYDROXYPHENYL)-2-METHOXYBENZAMIDE 4-chloro-2-hydroxy-N-(4-hydroxyphenyl)benzamide 2-hydroxy-N-(4-hydroxyphenyl)-N-methylbenzamide AURORA 3537 AURORA 2063
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