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| | NAPHTHOQUINE PHOSPHATE Basic information |
| Product Name: | NAPHTHOQUINE PHOSPHATE | | Synonyms: | NAPHTHOQUINE PHOSPHATE;Naphthalene phosphoric acid phenol quinoline;Naphathoquine Phosphate;4-[(7-Chloro-4-quinolinyl)amino]-2-[[(tert-butyl)amino]methyl]-5,6,7,8-tetrahydro-1-naphthalenol phosphate;NAPHTHOQUINE PHOSPHATE USP/EP/BP | | CAS: | 173531-58-3 | | MF: | C24H31ClN3O5P | | MW: | 507.95 | | EINECS: | | | Product Categories: | | | Mol File: | 173531-58-3.mol |  |
| | NAPHTHOQUINE PHOSPHATE Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in DMSO | | form | Powder |
| | NAPHTHOQUINE PHOSPHATE Usage And Synthesis |
| Biological Activity | malaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. naphthoquine phosphate is a antimalarial drug developed in china. | | in vitro | naphthoquine phosphate showed promising antimalaria acitivities against various p. falciparum strains. moreover, previoius study highlighted that naphthoquine did not lose potency when tested against chloroquine resistant strains [1]. | | in vivo | in an study aiming to investigate the antimalarial activity of naphthoquine phosphate combined with artemisinine against plasmodium knowlesi in rhesus monkey, it was found that the combination of naphthoquine phosphate and artemisinine was superior to the single component and the optimum proportion in the combination is 1 : 2.5 in treating p. knowlesi infection in monkeys [2]. | | target | malaria | | IC 50 | 0.1-5.2 nm for various p. falciparum strains [1] | | references | [1] delves m, plouffe d, scheurer c, meister s, wittlin s, winzeler ea, sinden re, leroy d. the activities of current antimalarial drugs on the life cycle stages of plasmodium: a comparative study with human and rodent parasites. plos med. 2012;9(2):e1001169.
[2] wang jy, ding db, li gf, zhao jh. therapeutic efficacy of naphthoquine phosphate combined with artemisinine against plasmodium knowlesi. zhongguo ji sheng chong xue yu ji sheng chong bing za zhi. 2008;26(6):442-4.
[3] tun t, tint hs, lin k, kyaw tt, myint mk, khaing w, tun zw. efficacy of oral single dose therapy with artemisinin-naphthoquine phosphate in uncomplicated falciparum malaria. acta trop. 2009;111(3):275-8. |
| | NAPHTHOQUINE PHOSPHATE Preparation Products And Raw materials |
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