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| | ACETOPHENAZINE MALEATE (200 MG) Basic information |
| | ACETOPHENAZINE MALEATE (200 MG) Chemical Properties |
| Melting point | 167-168.5° | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | neat | | color | Yellow to Orange | | Stability: | Hygroscopic |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | RTECS | OB4180000 | | Toxicity | LD50 orally in rats: 433 mg/kg (Schafer) |
| | ACETOPHENAZINE MALEATE (200 MG) Usage And Synthesis |
| Originator | Tindal ,Schering ,US ,1961 | | Uses | Antipsychotic. | | Definition | ChEBI: A maleate salt obtained by combining acetophenazine with two molar equivalents of maleic acid. | | Manufacturing Process | The requisite intermediate, 10-(3-chloropropyl)-2-acetylphenothiazineis
prepared as follows: To a suspension of sodium amide (from 3 grams of
sodium) in 300 ml of liquid ammonia is added 30 grams of 2-
acetylphenothiazine. After stirring for one hour, there is added 19 grams of 1-
bromo-3-chloropropane. The ammonia is allowed to evaporate and the residue
is diluted with 200 ml of water. The mixture is extracted with ether and the
ether solution is dried over anhydrous sodium sulfate, filtered and
concentrated.
The residue consists of crude 10-(3-chloropropy1)-2-acetylphenothiazine as a
viscous oil and is used in the next step without further purification. The crude
base obtained from the reaction of 10-(3-chloropropyl)-2-acetylphenothiazine
with 1-(2-hydroxyethyl)piperazine is purified by conversion to its dimaleate
salt, MP 167-168.5°C from ethanol. | | Brand name | Tindal (Schering). | | Therapeutic Function | Tranquilizer | | Safety Profile | Poison by ingestion, intraperitoneal,and intravenous routes. Severe eye irritant. |
| | ACETOPHENAZINE MALEATE (200 MG) Preparation Products And Raw materials |
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