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| | Suprofen Basic information |
| | Suprofen Chemical Properties |
| Melting point | 278°C | | Boiling point | 373.57°C (rough estimate) | | density | 1.2959 (rough estimate) | | refractive index | 1.5050 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.5 mg/ml | | pka | 3.91(at 25℃) | | form | Powder | | Water Solubility | soluble | | CAS DataBase Reference | 40828-46-4(CAS DataBase Reference) |
| RIDADR | 3249 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 2934990002 | | Toxicity | LD50 (7 days post-drug) in mice, rats, guinea pigs, dogs (mg/kg): 590, 353, 280, 160 orally (Niemegeers) |
| | Suprofen Usage And Synthesis |
| Description | Suprofen is an arylpropionic acid analgesic/antiinflammatory agent with close
structural resemblance to ketoprofen. It is more potent in many assays than
indomethacin and ketoprofen and appears better tolerated. | | Chemical Properties | Off-White to Light-Brown | | Originator | Janssen (Belgium) | | Uses | Prostaglandin biosynthesis inhibitor. Analgesic | | Uses | Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic. | | Definition | ChEBI: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group. | | Brand name | Profenal (Alcon);Algiamida;Algiasdi;Bordol;Erdol;Masterfen;Sufenid;Supranol;Surfex;MALDOCIL. | | Veterinary Drugs and Treatments | Suprofen is a non-steroidal anti-inflammatory agent similar to
flurbiprofen. Suprofen and flurbiprofen are phenylalkanoic acids
that inhibit the cyclo-oxygenase enzymes responsible for conversion
of arachadonic acid from cell membranes into various prostaglandins.
These prostaglandins mediate certain aspects of ocular
inflammation including disruption of the blood-aqueous barrier,
uveal vasodilation, increases in intraocular pressure, and leakage of
white blood cells and protein from uveal vessels into the aqueous
humor. Prostaglandins cause iris sphincter constriction (miosis)
independent of cholinergic mechanisms. Suprofen can inhibit this
intraocular miosis and may also be useful in the management of
uveal inflammation (usually in addition to topical steroids). |
| | Suprofen Preparation Products And Raw materials |
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