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| | Thiamine nitrate Chemical Properties |
| Melting point | 374-392 °C | | storage temp. | 2-8°C | | solubility | Sparingly soluble in water, freely soluble in boiling water, slightly soluble in alcohol and in methanol. | | pka | 4.8(at 25℃) | | form | solid | | color | White to Off-White | | Odor | wh. cryst. or cryst. powd., sl. char. odor | | Merck | 14,9295 | | BRN | 3857790 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | UIERGBJEBXXIGO-UHFFFAOYSA-N | | CAS DataBase Reference | 532-43-4(CAS DataBase Reference) | | EPA Substance Registry System | Thiamine nitrate (532-43-4) |
| Safety Statements | 22-24/25 | | WGK Germany | 1 | | RTECS | XI7400000 | | TSCA | Yes | | HS Code | 29362200 |
| | Thiamine nitrate Usage And Synthesis |
| Description | Thiamine nitrate is the thiamine salt formed from one mole of thiamine base and one mole of nitric acid. It occurs as an anhydrous crystalline solid of low hygroscopicity. Thiamin (vitamin B1) is a member of the vitamin B complex. Attributing to low hydroscopicity, thiamine nitrate works as a more stable form of thiamine in pharmaceutical preparations.
Thiamine nitrate is preferred to be used for the preparation of multivitamins and as a food fortification in dry blends and dry products such as in wheat flour.
| | References | [1] Food and Agriculture Organization of the United Nations, Food Fortification: Technology and Quality Control: Report of an FAO technical meeting Rome, 1995
[2] Ronald R. Eitenmiller, W. O. Landen Jr and Lin Ye, Vitamin Analysis for the Health and Food Sciences, Second Edition, 2008
[3] Thomas J. Macek, Beate A. Feller and Edward J. Hanus, Pharmaceutical studies with thiamine mononitrate, Journal of Pharmaceutical Sciences, 1950, vol. 39, 365-369
| | Description | Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro when used at concentrations ranging from 1 to 100 μM. In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication. It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice. Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2). | | Chemical Properties | White or almost white, crystalline powder or small, colourless crystals. | | Uses | Thiamine Nitrate is an orally administered vitamin. Thiamine is a essential nutrient required for carbohydrate metabolism and is involved in nerve function. | | Uses | Vitamin B1. | | General Description | Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine Nitrate is a mononitrate salt of thiamine. It is synthesized from thiamine hydrochloride following a sequence of steps. Thiamine Nitrate is used as a dietary supplement in crackers, eggs substitute and enriched flour. | | Safety Profile | Poison by intravenous
and intraperitoneal routes. A powerful
oxidizer. When heated to decomposition it emits very toxic fums of SOx, and NOx. See also NITRATES. |
| | Thiamine nitrate Preparation Products And Raw materials |
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