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| | 2-Aminoadenosine Basic information |
| | 2-Aminoadenosine Chemical Properties |
| Melting point | 241-243°C (dec.) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Aqueous Acid (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Ethanol | | form | Powder | | Boiling point | 798.5±70.0 °C(Predicted) | | density | 2.25±0.1 g/cm3(Predicted) | | pKa | 13.10±0.70(Predicted) | | color | White to Off-White | | InChIKey | ZDTFMPXQUSBYRL-UUOKFMHZSA-N | | CAS DataBase Reference | 2096-10-8(CAS DataBase Reference) |
| Safety Statements | 24/25 | | HS Code | 29389090 |
| Provider | Language |
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ALFA
| English |
| | 2-Aminoadenosine Usage And Synthesis |
| Description | 2-Aminoadenosine is a known analogue of adenosine that engages in three hydrogen bonds of the W-C type, adding considerable stability to the double helix. | | Chemical Properties | White Powder | | Uses | 2-Aminoadenosine is a nucleoside analog as inhibitor or substrate of adenosine kinase from M. tuberculosis. It is also used to synthesize 2′-O-methyl and 3′-O-methyl Guanosine. | | Definition | ChEBI: 2-Aminoadenosine is a purine nucleoside. | | Synthesis | The synthesis of 2-aminoadenosine (2-AA): Assays were performed in 5 and 10% of aprotic dipolar co-solvents, at 60°C, twelve units/ml cell lysate were added to 150 ml of a solution kept thermostatically at 60 °C, and having the following composition of substrate solutions: 15mM Uridine/2 ' -Deoxyuridine,5 mM 2,6-Diaminopurine, and 30 mM potassium phosphate buffer, pH 7. After 5 hours, the reaction mixture was filtered by centrifugation at 2000 x g for 30 min, at 4°C, through an Amicon ultra-4 Centrifugal Filter Devices (Millipore, Bedford, MA) with a 3000-Da cutoff, and the filtrate was recovered. 
| | References | Pyrazolo[3,4-d]pyrimidine ribonucleosides related to 2-aminoadenosine and isoguanosine: synthesis, deamination and tautomerism. DOI: 10.1039/B708736E
An Efficient Process for Synthesis of 2′-O-methyl and 3′-O-methyl Guanosine from 2-aminoadenosine Using Diazomethane and the Catalyst Stannous Chloride. DOI: 10.1080/15257770500544529 |
| | 2-Aminoadenosine Preparation Products And Raw materials |
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