ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Glutamic acid derivatives (2S,4R)-4-METHYLGLUTAMIC ACID

(2S,4R)-4-METHYLGLUTAMIC ACID

(2S,4R)-4-METHYLGLUTAMIC ACID Basic information
Product Name:(2S,4R)-4-METHYLGLUTAMIC ACID
Synonyms:SYM 2081;ERYTHRO-4-METHYL-L-GLUTAMIC ACID;(2S,4R)-(+)-2-Amino-4-methylpentanedioic acid;(2S,4R)-4-METHYLGLUTAMIC ACID;(2S,4R)-(+)-2-AMINO-4-METHYLPENTANEDIOIC ACID 99%;(2S-R)-4-METHYLGLUTAMIC ACID;(4R)- 4-Methyl-L-glutamic Acid;erythro-L-4-Methylglutamic Acid
CAS:31137-74-3
MF:C6H11NO4
MW:161.16
EINECS:
Product Categories:Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents;Neurochemicals
Mol File:31137-74-3.mol
(2S,4R)-4-METHYLGLUTAMIC ACID Structure
(2S,4R)-4-METHYLGLUTAMIC ACID Chemical Properties
Melting point 178 °C
Boiling point 287.44°C (rough estimate)
density 1.3482 (rough estimate)
refractive index 1.4230 (estimate)
storage temp. Store at RT
solubility H2O: >10 mg/mL
form solid
pka2.34±0.21(Predicted)
color white
CAS DataBase Reference31137-74-3(CAS DataBase Reference)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
(2S,4R)-4-METHYLGLUTAMIC ACID Usage And Synthesis
Chemical PropertiesWhite
UsesA highly selective and potent agonist for kainate receptors.
Biological ActivityPotent and highly selective kainate receptor agonist, with an IC 50 for inhibition of [ 3 H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™ .
(2S,4R)-4-METHYLGLUTAMIC ACID Preparation Products And Raw materials
Raw materials2-METHYL-4-OXOPENTANEDIOIC ACID-->(2S,4S)-4-METHYLGLUTAMIC ACID
(+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID, [4,5-3H] FMOC-L-GLA(OME)2-OH (2S,4R)-4-METHYLGLUTAMIC ACID L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID (2S,2'R,3'R)-2-(1'-3H,2',3'-DICARBOXYCYCLOPROPYL)GLYCINE DCG IV (2S,4R)-GAMMA-(2-NAPHTHYLMETHYL)-GLUTAMIC ACID ABHXD-I HYDROCHLORIDE TRITYL-L-TRANSPRO(4-COOME)-OME (1S,3R)-ACPD (2S)-2-AMINO-2-[(1S,2S)-2 CARBOXYCYCLOPROP-1-YL]-3-([2,7-3H]XANTH-9-YL) PROPANOIC ACID BOC-L-GLA(OBZL)2-OH H-GLA-OH (+/-)-1-AMINOCYCLOPENTANE-CIS-1,3-DICARBOXYLIC ACID Z-L-GLA(OTBU)2-OH FMOC-L-GLA(OET)2-OH 1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLIC ACID 4-DIMETHYL-L-GLUTAMIC ACID
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