ChemicalBook Product Catalog API Synthetic Anti-infective Drugs Sulfonamides and synergist Mafenide hydrochloride

Mafenide hydrochloride

Mafenide hydrochloride Basic information
Product Name:Mafenide hydrochloride
Synonyms:masudin;morfanil;p-aminomethylphenylsulfonamidehydrochloride;sulfamylonhydrochloride;sulfbenzaminehydrochloride;MARFANIL;MARFANIL HYDROCHLORIDE;MAFENIDE HYDROCHLORIDE
CAS:138-37-4
MF:C7H11ClN2O2S
MW:222.69
EINECS:205-325-3
Product Categories:
Mol File:138-37-4.mol
Mafenide hydrochloride Structure
Mafenide hydrochloride Chemical Properties
Melting point 261-263 °C(lit.)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form neat
color White
Merck 13,5671
InChIKeySIACJRVYIPXFKS-UHFFFAOYSA-N
CAS DataBase Reference138-37-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 42/43
Safety Statements 22-36/37-45
WGK Germany 2
RTECS XT5425000
HS Code 29350090
ToxicityLD50 in rats, mice (mg/kg): 1170, 900 i.v. (Skulan, Hoppe)
MSDS Information
ProviderLanguage
SigmaAldrich English
Mafenide hydrochloride Usage And Synthesis
UsesAntibacterial;Inhibitor of folic acid biosynthesis
Purification MethodsCrystallise the salt from dilute HCl or 95% EtOH and dry it in a vacuum at 100o. It is an antibacterial. [Miller et al. J Am Chem Soc 62 2099 1940, Bergeim & Barker J Am Chem Soc 66 1459 1944.] The sulfate salt has m 254-255o (from aqueous EtOH). [Beilstein 14 III 2223, 14 IV 2799.]
Mafenide hydrochloride Preparation Products And Raw materials
Raw materialsEthanol-->Hydrochloric acid-->Ethyl acetate-->Sulfuric acid-->Dichloromethane-->Chloroform-->Triethylamine-->Ammonia-->Acetyl chloride-->Chlorosulfonic acid-->Benzylamine
Sulfasalazine 4-(AMINOSULFONYL)-5-CHLOROPHTHALIMIDE REACTIVE BLUE 15 D-Glucosamine hydrochloride 4-(AMINOMETHYL)BENZENESULPHONAMIDE HYDROCHLORIDE HYDRATE Mafenide hydrochloride 2-Aminoethylammonium chloride Benzene-1,3-diamine dihydrochloride Glycinamide hydrochloride Silver sulfadiazine Betaine hydrochloride clorexolone Sulfanilamide p-Phenylenediamine dihydrochloride 4-AMINOAZOBENZENE HYDROCHLORIDE 4-([3-(2-CHLORO-6-FLUOROBENZYL)-4-HYDROXY-2-OXO-1(2H)-PYRIDINYL]METHYL)BENZENESULFONAMIDE Cysteamine hydrochloride Fomesafen
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