ChemicalBook Product Catalog Chemical Reagents Organic reagents Hydroxylamine 1-NAPHTHOHYDROXAMIC ACID

1-NAPHTHOHYDROXAMIC ACID

1-NAPHTHOHYDROXAMIC ACID Basic information
Product Name:1-NAPHTHOHYDROXAMIC ACID
Synonyms:Naphthalene-1-carbohydroximic acid;N-Hydroxy-1-naphthalenecarboxamide;a-Naphthohydroxamic acid;NSC 57457;HDAC Inhibitor XIX, Compound 2;N-HYDROXYNAPHTHALENE-1-CARBOXAMIDE;alpha-naphthohydroxamicacid;n-hydroxy-1-naphthalenecarboxamid
CAS:6953-61-3
MF:C11H9NO2
MW:187.19
EINECS:
Product Categories:Hydroxylamines;Hydroxylamines (N-Substituted)
Mol File:6953-61-3.mol
1-NAPHTHOHYDROXAMIC ACID Structure
1-NAPHTHOHYDROXAMIC ACID Chemical Properties
Melting point 176-178 °C
density 1.291±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
form White solid
pka8.91±0.30(Predicted)
color white to tan
Safety Information
Risk Statements 52
WGK Germany 3
RTECS QJ1894500
HS Code 2928009090
MSDS Information
1-NAPHTHOHYDROXAMIC ACID Usage And Synthesis
Uses1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.
Biochem/physiol Actions1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
1-NAPHTHOHYDROXAMIC ACID Preparation Products And Raw materials
Pyrazine 2-Naphthohydroxamic acid, O-acetate ester Naphthaloximidodiethyl thiophosphate N-HYDROXYNAPHTHALIMIDE TRIFLATE 99+% N-HYDROXYNAPHTHALIMIDE 1-NAPHTHOHYDROXAMIC ACID Naftalofos N-HYDROXYNAPHTHALIMIDE SODIUM SALT
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