1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Basic information

Product Name:	1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde
Synonyms:	1-(tert-butoxycarbonyl)-4-formylpiperidine;1-BOC-4-FORMYLPIPERIDINE 95%;1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde;Piperidine-4-carboxaldehyde, N-BOC protected;TERT-BUTYL 4-FORMYLPIPERIDINE-1-CARBOXYLATE;1-Piperidinecarboxylic acid, 4-formyl-, 1,1-dimethylethyl ester;1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXALDEHYDE;tert-Butyl 4-formyl-1-piperidinecarboxylate
CAS:	137076-22-3
MF:	C11H19NO3
MW:	213.27
EINECS:	203-107-6
Product Categories:	C11;Chemical Synthesis;Piperidine;Heterocyclic Building Blocks;Organic Building Blocks;Piperidines;Carbonyl Compounds;Heterocycles;pharmacetical;Aldehydes;Pyrans, Piperidines & Piperazines;Inhibitors;Building Blocks;C10-C12
Mol File:	137076-22-3.mol

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Chemical Properties

Melting point	34-40℃
Boiling point	295.4±33.0 °C(Predicted)
density	1.114±0.06 g/cm3(Predicted)
Fp	>110℃
storage temp.	2-8°C
solubility	Soluble in methanol.
pka	-2.13±0.40(Predicted)
form	Oil
color	Clear Yellow
Sensitive	Air Sensitive
InChIKey	JYUQEWCJWDGCRX-UHFFFAOYSA-N
CAS DataBase Reference	137076-22-3(CAS DataBase Reference)

Safety Information

MSDS Information

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Usage And Synthesis

Chemical Properties	Clear Yellow Oil
Uses	Reactant for synthesis of:• ;Pim-1 inhibitors1• ;Selective GPR119 agonists for type II diabetes2• ;M-tropic (R5) HIV-1 replication inhibitors3• ;HDAC inhibitors4• ;Selective 5-HT6 antagonists5Reactant for three-component vinylogous Mannich reactions6
Uses	1-Boc-piperidine-4-carboxaldehyde is used as reactant for synthesis of Pim-1 inhibitors, selective GPR119 agonists for type II diabetes, M-tropic (R5) HIV-1 replication inhibitors, HDAC inhibitors and selective 5-HT6 antagonists. It is also used as reactant for three-component vinylogous Mannich reactions
Uses	An intermediate for polycyclic indazole derivatives that are ERK inhibitors.

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Preparation Products And Raw materials

Raw materials	Dichloromethane-->Lithium Aluminum Hydride-->Di-tert-butyl dicarbonate-->Sodium acetate-->Manganese dioxide-->Pyridinium chlorochromate-->Isonipecotic acid-->4-Piperidinemethanol
Preparation Products	tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate-->tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate-->1-BOC-PIPERIDIN-4-YLPROPIONIC ACID-->TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE-->1-Boc-4-(2-aMino-1-hydroxybutyl)piperidine-->tert-butyl 4-(2-fluoro-3-hydroxypropyl)piperidine-1-carboxylate-->1-Boc-4-(1-phenylacetoxyallyl)piperidine-->CHEMBRDG-BB 4005904

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