P-TOLUENESULFONYL FLUORIDE

P-TOLUENESULFONYL FLUORIDE Basic information

Product Name:	P-TOLUENESULFONYL FLUORIDE
Synonyms:	4-TOLUENESULPHONYL FLUORIDE;4-TOLUENESULFONYL FLUORIDE;4-METHYLBENZENESULFONYL FLUORIDE;P-TOLUENESULFONYL FLUORIDE;P-TOLUENESULPHONYL FLUORIDE;TOSYL FLUORIDE;4-methyl-benzenesulfonylfluorid;p-Fluorosulfonyltoluene
CAS:	455-16-3
MF:	C7H7FO2S
MW:	174.19
EINECS:	207-238-6
Product Categories:	Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
Mol File:	455-16-3.mol

P-TOLUENESULFONYL FLUORIDE Chemical Properties

Melting point	41-42 °C(lit.)
Boiling point	112 °C16 mm Hg(lit.)
density	1.2768 (estimate)
Fp	222 °F
Water Solubility	Hydrolyzes in water.
Sensitive	Moisture Sensitive
BRN	2208423
Exposure limits	ACGIH: TWA 2.5 mg/m3 NIOSH: IDLH 250 mg/m3
CAS DataBase Reference	455-16-3(CAS DataBase Reference)
EPA Substance Registry System	Benzenesulfonyl fluoride, 4-methyl- (455-16-3)

Safety Information

Hazard Codes	C
Risk Statements	20/21/22-34
Safety Statements	22-26-27-36/37/39-45
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS	XT8050000
Hazard Note	Corrosive
TSCA	T
HazardClass	8
PackingGroup	II
HS Code	29049095
Toxicity	rat,LD50,intraperitoneal,200mg/kg (200mg/kg),Nature. Vol. 173, Pg. 33, 1954.

MSDS Information

P-TOLUENESULFONYL FLUORIDE Usage And Synthesis

Chemical Properties	White to beige fused mass
Uses	p-Toluenesulfonyl fluoride is used for sulfonylation of organometallic reagents as a simple, one-step synthesis of sulfones. It is useful in the treatment of Alzheimer?s disease. It is used to study the DNS polymerase from spinach leaf extracts. It was used in isolation and separation of Pseudomonas aeruginosa membranes by density sucrose gradient centrifugation.
Uses	Protease inhibitor.
General Description	p-Toluenesulfonyl fluoride is a peroxygen bleach activator and is also useful in the treatment of Alzheimer′s disease.

P-TOLUENESULFONYL FLUORIDE Preparation Products And Raw materials

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