Ethyl 4-chloroacetoacetate

Ethyl 4-chloroacetoacetate Basic information

Product Name:	Ethyl 4-chloroacetoacetate
Synonyms:	AKOS BBS-00004336;4-CHLOROACETOACETIC ACID ETHYL ESTER;BUTANOIC ACID, 4-CHLORO-3-OXO-ETHYL ESTER;ETHYL 4-CHLOROACETOACETATE;ETHYL 4-CHLORO-3-OXOBUTANOATE;ETHYL-GAMMA-CHLOROACETOACETATE;Amlodipine Impurity 66;4-chloroacetoacetate reference substance
CAS:	638-07-3
MF:	C6H9ClO3
MW:	164.59
EINECS:	211-317-0
Product Categories:	C6 to C7;Carbonyl Compounds;Pharmaceutical Intermediates;Halogen compounds;Esters;Aliphatics;1;bc0001
Mol File:	638-07-3.mol

Ethyl 4-chloroacetoacetate Chemical Properties

Melting point	-8 °C
Boiling point	115 °C/14 mmHg (lit.)
density	1.218 g/mL at 25 °C (lit.)
vapor pressure	7hPa at 20℃
refractive index	n20/D 1.452(lit.)
Fp	206 °F
storage temp.	2-8°C
solubility	47.0g/l
pka	9.56±0.46(Predicted)
form	Liquid
color	Clear colorless to pale reddish-yellow
PH	2.9 (10g/l, H2O, 20℃)
explosive limit	1.8%(V)
Water Solubility	47.5 g/L (20 ºC)
BRN	1761275
InChIKey	OHLRLMWUFVDREV-UHFFFAOYSA-N
LogP	0.68 at 25℃
CAS DataBase Reference	638-07-3(CAS DataBase Reference)
NIST Chemistry Reference	Butanoic acid, 4-chloro-3-oxo-, ethyl ester(638-07-3)
EPA Substance Registry System	Ethyl 4-chloroacetoacetate (638-07-3)

Safety Information

Hazard Codes	T,N,C
Risk Statements	25-34-51/53-24/25-36
Safety Statements	26-36-45-61-36/37/39-27
RIDADR	UN 2922 8/PG 2
WGK Germany	3
RTECS	AK5110000
F	8-10-19-21
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29183000

MSDS Information

Provider	Language
Ethyl 4-chloro-3-oxobutanoate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Ethyl 4-chloroacetoacetate Usage And Synthesis

Chemical Properties	Ethyl 4-chloroacetoacetate is colorless to pale reddish-yellow clear liquid
Uses	Ethyl-4-chloracetoacetate (CAAEt) is used as intermediate for organic syntheses, e.g. ethyl 4-chloro-3-arylaminocrotonates, diethyl succinylsuccinate, 2-alkyl-4-hydroxy-6-chloromethylpyrimidines, 4- chloromethylcoumarines. Product Data Sheet
Uses	Ethyl 4-chloroacetoacetate is used as a precursor in the preparation of phosphorous ylides. It finds application in regular film coating, pharmaceutical coating and formulation.

Ethyl 4-chloroacetoacetate Preparation Products And Raw materials

Raw materials

Ethanol-->Chlorine-->Acetyl ketene-->METHANE

Preparation Products

4-CHLOROMETHYL-6-METHYL-CHROMEN-2-ONE-->ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE-->ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE-->2-(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID-->Diethyl succinosuccinate-->ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE-->4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE-->4-Thiazoleacetic acid, ethyl ester-->6-(Chloromethyl)uracil-->(2-PHENYL-THIAZOL-4-YL)-ACETIC ACID-->Ethyl (R)-(-)-4-cyano-3-hydroxybutyate-->Ethyl 4-(benzyloxy)-3-oxobutanoate-->DL-CARNITINE-->ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE

Ethyl acetoacetate ETHYL (Z)-2-(2-CHLOROACETYL)-3-ETHOXY-2-PROPENOATE Ethyl 4,4,4-trifluoroacetoacetate Trinexapac-ethyl Ethanol Ethyl 4-chloroacetoacetate 4,4,4-TRICHLOROACETOACETIC ACID ETHYL ESTER Ethylparaben ISOXADIFEN-ETHYL Ethyl acetate Ethyl propiolate Ethyl acrylate SALOR-INT L169625-1EA Ethyl 2-methylacetoacetate Ethyl2-chloroacetoacetate,97%,ETHYL 2-CHLOROACETOACETATE,ETHYL ALPHA-CHLOROACETOACETATE,ETHYL 2-CHLOROACETOACETATE, WACKERQUALIT Y Ethyl chloroacetate Ethyl cyanoacetate Ethyl 4-bromoacetoacetate

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