1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Basic information
Product Name:1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride
Synonyms:1-(1,4-benzodioxan-2-ylcarbonyl)piperazine hydrochloride;N-[(1,4-Benzodioxin-2-yl)carbonyl]piperazine hydrochloride;2-(1-Piperazinylcarbonyl)-1,4-benzodioxane Hydrochloride;4-Benzodioxan-2-carbonyl)-piperazine hydrochloride;Doxazosin Related Compound A (20 mg) (N-(1,4-benzodioxane-2-carbonyl)piperazine hydrochloride);Methanone,(2,3-dihydro-1,4-benzodioxin-2-yl)-1-piperazinyl-, hydrochloride (1:1);(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)Methanone hydrochloride;N-(1,4-Benzodioxane-2-carbonyl)piperazine Hydrochloride
CAS:70918-74-0
MF:C13H17ClN2O3
MW:284.74
EINECS:415-660-9
Product Categories:(intermediate of doxazosin);(intermediate of doxazocin mesylate);Piperidines, Piperidones, Piperazines
Mol File:70918-74-0.mol
1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Structure
1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Chemical Properties
Melting point 105-108°C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form powder to crystal
color White to Almost white
Stability:Hygroscopic
CAS DataBase Reference70918-74-0(CAS DataBase Reference)
Safety Information
Hazard Codes T;N,Xi,N,T
Risk Statements 23/24/25-48/22-51/53
Safety Statements 45-53-61
RIDADR UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
Hazard Note Irritant
HazardClass 6.1
PackingGroup III
HS Code 2934990002
MSDS Information
1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Usage And Synthesis
Uses1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine Monohydrochloride (Doxazosin EP Impurity B) is an impurity of Doxazosin (D537500), a selective a1-adrenoceptor antagonist. Doxazosin relaxes smooth muscles of the prostate.
1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Preparation Products And Raw materials
Raw materialsETHYL 1,4-BENZODIOXAN-2-CARBOXYLATE-->2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBONYL CHLORIDE-->2-HYDROXYMETHYL-1,4-BENZODIOXANE-->Piperazine
Doxazosin Related Compound F (15 mg) (N,N'-bis(1,4-benzodioxane-2-carbonyl)piperazine) 1-(1,4-Benzodioxane-2-carbonyl)piperazine 1-(CHLOROACETYL)-4-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLCARBONYL)PIPERAZINE 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Topotecan hydrochloride DOXAZOSIN MESILATE IMP. B (EP) AS HYDROCHLORIDE: 1-[(2RS)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLCARBONYL]PIPERAZINE HYDROCHLORIDE Piperazine citrate 1-(5-CHLORO-2-METHYLPHENYL)-4-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLCARBONYL)PIPERAZINE Benzo[b]thien-2-ylboronic acid Piperazine Doxazosin p-Phenylenediamine dihydrochloride CALCIUM DODECYLBENZENE SULFONATE DODECYLBENZENE 1,4-Benzodioxan Dihydromyrcenol 1-(3-CHLOROPHENYL)-4-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLCARBONYL)PIPERAZINE Dodecylbenzenesulphonic acid

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