Nefiracetam

Nefiracetam Basic information

Product Name:	Nefiracetam
Synonyms:	n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;NEFIRACETAM;2-oxo-1-pyrrolidinylaceticacid,2,6-dimethylanilide;dm9384;dmppa;n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamid;DM-9384, (2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide);DMMPA
CAS:	77191-36-7
MF:	C14H18N2O2
MW:	246.3
EINECS:	636-080-4
Product Categories:	Pharmaceutical intermediate;TRANSLON;Nootropic;Smart drug;BDO
Mol File:	77191-36-7.mol

Nefiracetam Chemical Properties

Melting point	151-155°C
Boiling point	458.5±33.0 °C(Predicted)
density	1.187±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO: >5mg/mL
pka	13.77±0.70(Predicted)
form	solid
color	white to off-white
Merck	14,6439
InChI	InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
InChIKey	NGHTXZCKLWZPGK-UHFFFAOYSA-N
SMILES	N1(CC(NC2=C(C)C=CC=C2C)=O)CCCC1=O
CAS DataBase Reference	77191-36-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
RTECS	UX9655650
HS Code	2933.79.1500
Toxicity	LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)

MSDS Information

Provider	Language
N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide	English

Nefiracetam Usage And Synthesis

Uses	analgesic, antiinflammatory
Uses	Nefiracetam improves post-ischemia evoke-nonconvulsive seizure by altering pro-inflammatory cytokines.
Definition	ChEBI: Nefiracetam is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.
Biological Activity	Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo .
storage	Store at RT

Nefiracetam Preparation Products And Raw materials

Raw materials

2,6-Dimethylaniline-->2-Chloro-N-(2,6-dimethylphenyl)acetamide-->Formaldehyde-->2-Pyrrolidinone-->4-Aminobutyric acid

Piracetam Nefiracetam Gabapentin Oxiracetam Citalopram Aniracetam Pramiracetam N-Methyl-2-pyrrolidone Pyrrocaine Pyrrole Polyvinylpyrrolidone 1-(2-aminoethyl)pyrrolidin-2-one MONOETHYLGLYCINEXYLIDIDE N-(2-METHYLPHENYL)-2-(PROPYLAMINO)ACETAMIDE N,N-Dimethylacetamide Lidocaine 1-[2-OXO-2-(4,4,6-TRIMETHYL-1-THIOXO-1,4-DIHYDRO-5H-[1,2]DITHIOLO[3,4-C]QUINOLIN-5-YL)ETHYL]PYRROLIDINE-2,5-DIONE Pyrrolidine

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