|
| | D(-)-Arginine Basic information |
| | D(-)-Arginine Chemical Properties |
| Melting point | 226 °C (dec.) (lit.) | | alpha | -28.5 º (c=8, 6 N HCl) | | Boiling point | 305.18°C (rough estimate) | | density | 1.2297 (rough estimate) | | refractive index | -23 ° (C=8, 6mol/L HCl) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Aqueous Acid (Slightly), Water (Slightly) | | pka | 2.49±0.24(Predicted) | | form | Solid | | color | White to Off-White | | Water Solubility | SOLUBLE | | Sensitive | Air Sensitive | | BRN | 1725412 | | InChIKey | ODKSFYDXXFIFQN-SCSAIBSYSA-N | | LogP | -0.999 (est) | | CAS DataBase Reference | 157-06-2(CAS DataBase Reference) | | EPA Substance Registry System | D-Arginine (157-06-2) |
| | D(-)-Arginine Usage And Synthesis |
| Description | D-arginine is the D-form of arginine, which is a kind of amino acids. It can be reacted with hydrogen peroxide for non-enzymatic synthesis of nitric oxide. It has certain pharmacological activities. For example, its derivative, 1-deamino-8-D-arginine vasopressin is useful for the management of haemophilia and von Willebrand’s disease. It also has the potential to inhibit the proliferation of certain cancer cells. In biological research, D-arginine is frequently used in the studies of L-arginine/nitric oxide pathway as an inactive form of L-arginine.
| | Chemical Properties | white to light yellow crystal powde | | Uses | Arginine is an essential amino acid found in food and plant sources, and many biological systems.
D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man.
D-Arginine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. D-Arginine specifically can inhibit arginine decarboxylase enzymes and also functions as a metabolite. | | Uses | 1-Deamino-8-D-arginine vasopressin makes a new pharmacological approach to the management of haemophilia and von Willebrand's disease. A novel nonenzymatic pathway for the generation of nitric oxide is by the reaction of hydrogen peroxide and d- or l-arginine. | | Definition | ChEBI: A D-alpha-amino acid that is the D-isomer of arginine. | | References | https://www.alfa.com/zh-cn/catalog/A16137/
Iannucci, N. B., et al. "Antiproliferative effect of 1-deamino-8-D-arginine vasopressin analogs on human breast cancer cells." Future Medicinal Chemistry 3.16(2011):1987-1993.
Ripoll, Giselle, et al. "Angiostatic activity of 1-Deamino-8-D-Arginine vasopressin and novel peptide analogues in breast cancer cells." Cancer Research 68(2008).
Navarro, Eduardo, et al. "Toxicological and Pharmacological Effects of D-Arginine." Basic & Clinical Pharmacology & Toxicology97.3(2005):149-154.
|
| | D(-)-Arginine Preparation Products And Raw materials |
|
