TRIMETHYLCOLCHICINIC ACID

TRIMETHYLCOLCHICINIC ACID Basic information
Product Name:TRIMETHYLCOLCHICINIC ACID
Synonyms:7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-benzo(a)heptalen-9(5h)-on;deacetylcholchiceine;desacetylcholchiceine;n-deacetyl-colchicein;TRIMETHYLCOLCHICINIC ACID;N-Deacetyl 10-Demethyl Colchicine;trimethyl-colchicinicaci;N-DEACETYLCOLCHICEINE
CAS:3482-37-9
MF:C19H21NO5
MW:343.37
EINECS:222-464-5
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;All Inhibitors;Inhibitors;AlkaloidsForensic and Veterinary Standards;Chemical Structure;Drugs of Abuse;Drugs&Metabolites;Neat CompoundsDrugs of Abuse;OthersAlphabetic;TP - TZ
Mol File:3482-37-9.mol
TRIMETHYLCOLCHICINIC ACID Structure
TRIMETHYLCOLCHICINIC ACID Chemical Properties
Melting point >230°C (dec.)
Boiling point 478.65°C (rough estimate)
density 1.2726 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. −20°C
solubility Chloroform (Slightly, Sonicated), DMSO (Slightly), Ethanol (Slightly), Methanol
form Solid
color Pale Green to Yellow
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36
WGK Germany 3
RTECS GH0960000
MSDS Information
ProviderLanguage
SigmaAldrich English
TRIMETHYLCOLCHICINIC ACID Usage And Synthesis
DescriptionA minor alkaloid of the colchicine class, this base was first isolated from the seeds and corms of Colchicum autumnale, Gloriosa virescens and Littoria modesta and subsequently by Russian workers from Merendera robusta Bge. Several specific rotations have been measured, e.g. [α]D - 184°, - 152° and - 180° (all in CHC13). The base is separated from the numerous accompanying alkaloids by chromatography and countercurrent distribution.
Chemical PropertiesYellow-green Solid
ReferencesPotesilova, Hrbek, Santavy, Collect. Czech. Chem. Commun., 32, 141 (1967)
Trudykulov, Yusupov, Sadykov, Khim. Prir. Soedin., 8,247 (1972)
Yusupov, Tr. Tashkent Fan., Uzbek SSR, 20, 24 (1972)

TRIMETHYLCOLCHICINIC ACID Preparation Products And Raw materials
TRIMETHYLCOLCHICINIC ACID DEMECOLCINE N-TRIFLUOROACETYL DEACETYLCOLCHICEINE DEMECOLCINE HYDROGEN BROMIDE SALT N-(2-MERCAPTOETHYL) DEMECOLCINE N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICEINE N-TRIFLUOROACETYL DEACETYLCOLCHICINE N-Acetyl trimethylcolchicinic acid methylether GLORIOSINE DEMECOLCEINE N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICINE (S)-7-[(2-HYDROXY-BENZYL)-METHYL-AMINO]-1,2,3,10-TETRAMETHOXY-6,7-DIHYDRO-5H-BENZO[A]HEPTALEN-9-ONE COLCHICINE SALICYLATE COLCHICINE METHANETHIOSULFONATE COLCHICINE, [RING C, METHOXY-3H] COLCHICINE, [RING C, METHOXY-14C] NBD-DEMECOLCIN COLCHICOSIDE

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