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| | Nitrendipine Basic information |
| | Nitrendipine Chemical Properties |
| Melting point | 1580C | | Boiling point | 492.4°C (rough estimate) | | density | 1.3595 (rough estimate) | | refractive index | 1.5700 (estimate) | | storage temp. | 2-8°C | | solubility | methanol: 15 mg/mL | | form | powder | | pka | 2.79±0.70(Predicted) | | color | yellow to green | | Water Solubility | Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water. | | Stability: | Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week. | | CAS DataBase Reference | 39562-70-4(CAS DataBase Reference) | | NIST Chemistry Reference | Nitrendipine(39562-70-4) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 1 | | RTECS | US5653000 | | Toxicity | LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann) |
| | Nitrendipine Usage And Synthesis |
| Description | Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged
therapeutic effect in comparison to nifedipine makes it useful in the once to twice
daily treatment of hypertension. | | Chemical Properties | Crystalline Solid | | Originator | Bayer (W. Germany) | | Uses | Antihypertensive;Calcium channel blocker | | Uses | Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. | | Uses | Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive. | | Definition | ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t
e treatment of hypertension. | | Brand name | Baypress (Bayer);BAYOTENSIN. | | General Description | Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension. | | Biological Activity | L-type calcium channel blocker. | | Biochem/physiol Actions | Ca2+ channel blocker; anti-hypertensive. | | storage | Store at RT | | References | 1) Meyer et al., (1981), (Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions); Arzneimittelforschung 31 407
2) Stoepel et al., (1981), Pharmacological studies of the antihypertensive effect of nitrendipine; Arzneimittelforschung 31 2056 |
| | Nitrendipine Preparation Products And Raw materials |
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