(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE

(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE Basic information
Product Name:(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE
Synonyms:((2R,3R)-butane-2,3-diyl)bis(diphenylphosphane);(R,R)-CHIRAPHOS;(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(+)-2,3-BIS(DIPHENYL PHOSPHINO)BUTANE;(2R,3R)-(+)-Bis(diphenylphosphino)butane, (R,R)-CHIRAPHOS;(R,R)-Chiraphos,97%;(2R,3R)-(+)-Bis(diphenylphosphino)butane, 98% (R,R)-CHIRAPHOS;(2R,3R)-(+)-2,3-Bis(diphenylphosphino)butane (R,R)-CHIRAPHOS
CAS:74839-84-2
MF:C28H28P2
MW:426.48
EINECS:
Product Categories:Chiral Phosphine;Pharmaceutical Intermediates
Mol File:74839-84-2.mol
(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE Structure
(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE Chemical Properties
Melting point 104-109 °C
Boiling point 529.2±33.0 °C(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form solid
color white
Sensitive Air Sensitive
CAS DataBase Reference74839-84-2
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 36/37/39-26-37/39
WGK Germany 3
TSCA No
HS Code 29310099
MSDS Information
ProviderLanguage
ACROS English
(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE Usage And Synthesis
Chemical Propertieswhite crystalline powder
Uses(2R,3R)-Bis(diphenylphosphino)butane is a reagent used in the synthesis of endothelin A receptor antagonists. Also used in the synthesis of (R)-Tolterodine and (S)-Tolterodine.
Purification MethodsIt recrystallises from absolute EtOH (~6g in 60mL) as colourless plates [Fryzuk & Bosnich J Am Chem Soc 99 6262 1977, Fryzuk & Bosnich J Am Chem Soc 101 3043 1979].
(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE Preparation Products And Raw materials
(2R,3R)-(-)-2,3-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene(1,5-cyclooctadiene)rhodium(I)tetrafluoroborate,min.97%(R,R)-NORPHOS-Rh (+)-DIOP 1,4-Bis(diphenylphosphino)butane (2R,3R)-(-)-2,3-BIS(DIPHENYLPHOSPHINO)BICYCLO[2.2.1]HEPT-5-ENE (+)-(3R,4R)-BIS(DIPHENYLPHOSPHINO)-1-BENZYLPYRROLIDINE(1,5-CYCLOOCTADIENE)RHODIUM (I) TETRAFLUOROBORATE (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE (3R,4R)-(+)-1-BENZYL-3,4-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE HYDROCHLORIDE (-)-DIOP [1,4-BIS(DIPHENYLPHOSPHINO)BUTANE](1,5-CYCLOOCTADIENE)RHODIUM(I) TETRA-FLUOROBORATE (+)-(3R,4R)-BIS(DIPHENYLPHOSPHINO)-1-BENZYLPYRROLIDINE (3R,4R)-(+)-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE (2S,3S)-(-)-BIS(DIPHENYLPHOSPHINO)BUTANE 1,4-Bis(diphenylphosphino)butane Monooxide (+)-2,3-O-Isopropyliden-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (BICYCLO[2.2.1]HEPTA-2,5-DIENE)[(2S,3S)-BIS(DIPHENYLPHOSPHINO)-BUTANE] RHODIUM(I) PERCHLORATE (R,R)-2,3-O-[(1'- DIPHENYLPHOSPHINO) BUT- 3'-YLIDENE]-2,3- DIHYDROXY - 1,4- BIS(DIPHENYLPHOSPHINO) BUTANE ([2S,3S]-BIS[DIPHENYLPHOSPHINO]BUTANE)(ETA3-ALLYL) PALLADIUM(II) PERCHLORATE DICHLORO[1,4-BIS(DIPHENYLPHOSPHINO)BUTANE]NICKEL(II)

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