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| | Pentafluoropyridine Basic information | | Synthesis |
| Product Name: | Pentafluoropyridine | | Synonyms: | Pentafluoropyridine 99%;PENTAFLUOROPYRIDINE;PERFLUOROPYRIDINE;PENTAFLUOROPYRIDINE, 99+%;2,3,4,5,6-PENTAFLUOROPYRIDINE;2,3,4,5,6-Pentafluoropyridine 99%;Pentafluoropyridine, 99+% 5GR;5-Chloro-2-caynopyridine | | CAS: | 700-16-3 | | MF: | C5F5N | | MW: | 169.05 | | EINECS: | 211-839-9 | | Product Categories: | organofluorine compounds;Fluoropyridines;Halopyridines;C5;Heterocyclic Building Blocks;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine | | Mol File: | 700-16-3.mol |  |
| | Pentafluoropyridine Chemical Properties |
| Melting point | -42 | | Boiling point | 83-85 °C | | density | 1.54 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.386(lit.) | | Fp | 75 °F | | storage temp. | Inert atmosphere,2-8°C | | form | Liquid | | pka | -12.08±0.28(Predicted) | | color | Clear colorless | | Specific Gravity | 1.62 | | Water Solubility | Not miscible or difficult to mix in water. | | BRN | 1427064 | | InChIKey | XTGOWLIKIQLYRG-UHFFFAOYSA-N | | CAS DataBase Reference | 700-16-3(CAS DataBase Reference) | | NIST Chemistry Reference | Pyridine, pentafluoro-(700-16-3) |
| | Pentafluoropyridine Usage And Synthesis |
| Synthesis | Historically, potassium fluoride has been used with solvents to perform the Halex reaction and Finger and Kruse established the use of polar aprotic solvents in the Halex reaction, with DMSO and DMF being used for the conversion of pentachloropyridine to pentafluoropyridine.
 | | Chemical Properties | CLEAR COLOURLESS LIQUID | | Uses | Pentafluoropyridine was used in the preparation of η2-C,C coordinated pentafluoropyridine complex. It was also used in the preparation of polyfluorinated coupling products via Pd(0)-catalyzed cross-coupling reaction with diarylzinc compounds. It was also used as derivatizing reagent in the sensitive GC-MS method for determination of the four endocrine disrupting chemicals. | | General Description | The reactions of pentafluoropyridine with cobalt(0) complex, Co(PMe3)4 was investigated. | | Purification Methods | Distil it through a concentric tube column; it has in cyclohexane at 256.8nm. [Chambers et al. J Chem Soc 3573 1964, NMR: Bell et al. J Fluorine Chem 1 51 1971.] The hexafluoroantimonate has m 98-102o(dec) after crystallisation from liquid SO2. [Beilstein 20/5 V 401.] |
| | Pentafluoropyridine Preparation Products And Raw materials |
| Raw materials | 2,3,5,6-tetrachloro-4-fluoropyridine-->3-Chloro-2,4,5,6-tetrafluoropyridine | | Preparation Products | 3,5-DIFLUORO-PYRIDIN-4-YLAMINE-->Pyrrolidine, 2,2,3,3,4,4,5,5-octafluoro-1-(trifluoromethyl)--->3,5-DIFLUOROPYRIDINE-4-CARBALDEHYDE-->3,4-Dichloro-2,5,6-trifluoropyridine-->3,5-Difluoropyridine-->2,3,5,6-Tetrafluoropyridine-->2,5-Difluoropyridine-->2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE-->2,3,4,6-TETRAFLUOROPYRIDINE-->3,4,5-Trifluoropyridine-->BENZOYL FLUORIDE-->2,3,4,5-Tetrafluoropyridine |
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