Phen-DC3 Trifluoromethanesulfonate Chemical Properties
Melting point
>260 °C(Solv: ethyl ether (60-29-7))
storage temp.
Store at -20°C
solubility
DMSO : ≥ 34 mg/mL (40.06 mM)
Safety Information
MSDS Information
Phen-DC3 Trifluoromethanesulfonate Usage And Synthesis
Biological Activity
Phen-DC3 Trifluoromethanesulfonate is a G4-specific ligand that inhibits the helicases FANCJ and DinG with IC50s of 65±6 and 50±10 nM, respectively.
in vitro
In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remains fully stable in both PIF1-treated and WT cells.
