5-ETHYL-2'-DEOXYURIDINE

5-ETHYL-2'-DEOXYURIDINE Basic information
Product Name:5-ETHYL-2'-DEOXYURIDINE
Synonyms:5-ethyldeoxyuridine;aedurid;beta-5-ethyldeoxyuridine;edoxudin;edu;5-Ethyl-durd;Aids021723;Aids-021723
CAS:15176-29-1
MF:C11H16N2O5
MW:256.26
EINECS:239-226-1
Product Categories:
Mol File:15176-29-1.mol
5-ETHYL-2'-DEOXYURIDINE Structure
5-ETHYL-2'-DEOXYURIDINE Chemical Properties
Melting point 152-153°
density 1.389±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form Solid
pka9.98(at 25℃)
color Pale Beige to Beige
Stability:Hygroscopic
Safety Information
WGK Germany 3
RTECS YU7500000
HS Code 29349990
MSDS Information
ProviderLanguage
SigmaAldrich English
5-ETHYL-2'-DEOXYURIDINE Usage And Synthesis
Chemical PropertiesEdoxudine is solid
Usesantiallergic, mast cell degranulation inhibitor, angiogenesis blocker
UsesEdoxudine was found to be a modulator of both antitumor action and pharmacokinetics of 5-Fluorouracil (F596000), a potent antineoplastic agent in clinical use.
Uses5-Ethyl-2’-deoxyuridine was found to be a modulator of both antitumor action and pharmacokinetics of 5-Fluorouracil (F596000), a potent antineoplastic agent in clinical use.
DefinitionChEBI: Edoxudine is a pyrimidine 2'-deoxyribonucleoside.
Biochem/physiol Actions5-Ethyl-2′-deoxyuridine (EUdR) is used as a 5-fluorouracil (FU) modulator. EtdUrd may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels.
5-ETHYL-2'-DEOXYURIDINE Preparation Products And Raw materials
2'-FLUORO-2'-ARABINOFURANOSYL-5-ETHYLURACIL, [3H]- 2'-DEOXY-3',5'-DI-O-(4-METHYLBENZOYL)-5-ETHYLURIDINE 5-ethyl-2'-deoxyuridine triphosphate 5-ETHYL-2'-DEOXYURIDINE 5-[N-(N-BIOTINYL-EPSILON-AMINOCAPROYL)-3-AMINOALLYL]-2'-DEOXYURIDINE-5'-TRIPHOSPHATE 5-(2-HYDROXYETHYL)-2'-DEOXYURIDINE 5-Isopropyl-2'-deoxyuridine (IP5dU) (AA-UTP) SODIUM SALT AMINOALLYL DUTP AMINOALLYL UTP 5-AMINOALLYLURIDINE-5'-TRIPHOSPHATE LITHIUM SALT AURORA KA-628 AURORA KA-627 5-AMINOALLYL-2'-DEOXYURIDINE 3',5'-DI-O-(P-TOLUOYL)-5-(2-HYDROXYETHYL)-2'-DEOXYURIDINE 5-carboxymethyluridine 5-PROPYNYLURIDINE 5-AMINOALLYL-2'-DEOXYURIDINE-5'-TRIPHOSPHATE LITHIUM SALT

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