(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Basic information

Product Name:	(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide
Synonyms:	(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide;ABL-001;ABL001;ABL-001;ABL-001; AB -001; ABL001; ASCIMINIB; ASCIMINIB FREE BASE;;asciminib free base;(R)-N- (4-(CHLORODIFLUOROMETHOXY)PHENYL)- 6-(3- HYDROXYPYRROLIDIN-1- YL)-5- (1H-PYRAZOL- 5-YL)NICOTI;EOS-61420;L1F3R18W77
CAS:	1492952-76-7
MF:	C20H18ClF2N5O3
MW:	449.84
EINECS:
Product Categories:
Mol File:	1492952-76-7.mol

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Chemical Properties

Boiling point	631.7±55.0 °C(Predicted)
density	1.518±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:93.0(Max Conc. mg/mL);206.74(Max Conc. mM) Ethanol:90.0(Max Conc. mg/mL);200.07(Max Conc. mM)
form	A crystalline solid
pka	10.81±0.70(Predicted)

Safety Information

MSDS Information

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Usage And Synthesis

Uses	Asciminib comprises ABL kinase inhibitors and/or SLC7A11 inhibitors for the treatment of cancer and central nervous system (CNS) disorders.

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Preparation Products And Raw materials

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