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Valsartan Impurity 1

Valsartan Impurity 1 Basic information
Product Name:Valsartan Impurity 1
Synonyms:N-((2'-(1H-tetrazol-5-yl);N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamide;Valsartan Desvalyl Impurity;Valsartan Impurity 73;Valsartan Desalkyl;Pentanamide, N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
CAS:914465-68-2
MF:C19H21N5O
MW:335.4
EINECS:
Product Categories:
Mol File:914465-68-2.mol
Valsartan Impurity 1 Structure
Valsartan Impurity 1 Chemical Properties
Melting point 191-197°C
density 1.186±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility Acetonitrilie (Slightly, Heated), Methanol (Slightly)
form Solid
pka4.16±0.10(Predicted)
color White to Off-White
Safety Information
MSDS Information
Valsartan Impurity 1 Usage And Synthesis
UsesN-((2''-(1H-Tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)pentanamide is an impurity of Valsartan (V095750), an antihypertensive and a nonpeptide angiotensin II AT1-receptor antagonist.
Valsartan Impurity 1 Preparation Products And Raw materials
N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate 1426129-50-1 enantioMer Valsartan N1-Trityl R-IsoMer L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE Valsartan Impurity 3 Sodium Salt 4-Bromomethyl-2-cyanobiphenyl Valsartan n-Propyl Valsartan N2-Trityl IMpurity Valsartan Isopropyl Ester Valsartan Impurity 6 ValsartanN-Oxide Valsartan N2-Trityl R-IsoMer Valsartan Methyl Ester Valsartan N1-Trityl IMpurity Valsartan Impurity 5 Valsartan Related Compound A Valsartan cyano analog methyl ester
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