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| | 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Basic information |
| Product Name: | 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline | | Synonyms: | 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline;EOS-61512;2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)benzenamine;BMS-986165 Related Compound 3;Benzenamine, 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)-;2-Methoxy-3-(1-methyl-1,2,4-triazol-3-YL)aniline;2-Methoxy-3-(1-methyl-1H-[1,2,4]triazol-3-yl)-phenylamine | | CAS: | 1609394-10-6 | | MF: | C10H12N4O | | MW: | 204.23 | | EINECS: | | | Product Categories: | | | Mol File: | 1609394-10-6.mol |  |
| | 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Chemical Properties |
| Boiling point | 437.6±55.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | solubility | DMSO (Slightly) | | pka | 3.45±0.10(Predicted) | | form | Solid | | color | Pale Orange to Brown |
| | 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Usage And Synthesis |
| Uses | 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline is used in the preparation of pyridazines which is a heterodimeric cytokines modulators for treatment of diseases. | | Synthesis | To a high pressure reactor flushed with nitrogen were charged methanol (8.0 kg/kg) and Compound 6 (1.0 kg). With careful exclusion of oxygen, sodium bicarbonate (0.6 kg/kg, 2.0 equiv.) and Pd/C (10% loading, 50 % wet, 0.02 kg/kg) were added. The reactor was pressurized with hydrogen (41-46 psi), and the reaction mixture was aged at 20 °C for 6 h then heated to 45 °C and aged till reaction reached completion. The reactor was flushed with nitrogen, and the reaction crude was filtered to remove Pd/C. Methanol (5 kg/kg) was used to aid the transfer. The combined filtrates were distilled under vacuum until total volume became approximately 2.5 L/kg. Water (10 kg/kg) was added, and the crude was distilled under vacuum until total volume became approximately 2.5 L/kg. The crude was heated to 70 °C. Brine (25 wt%, 9.0 kg/kg) was added, and the resulting crude was agitated for 6 h at 70 °C. After cooling down to 0 °C, the crude was further aged for 6 h. Product was isolated by filtration. The cake was washed with brine (pre-cooled to 0 °C, 25 wt%, 2.0 kg/kg), and dried under vacuum at 45 °C. 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline was isolated in 99 AP and 88% yield.
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| | 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Preparation Products And Raw materials |
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