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| | CROCIN Chemical Properties |
| Melting point | 186° (effervescence) | | Boiling point | 1169.0±65.0 °C(Predicted) | | density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly, Heated), Methanol (Very Slightly, Sonicated) | | pka | 12.20±0.70(Predicted) | | form | Powder | | color | Orange to Very Dark Purple | | Merck | 14,2589 | | Stability: | Light Sensitive | | InChIKey | OXNHRKGZZFWUQZ-QORFUXSJSA-N | | LogP | -4.742 (est) | | CAS DataBase Reference | 42553-65-1 |
| | CROCIN Usage And Synthesis |
| Introduction | Crocin (crocin) is also known as a-crocin and crocetin. It is a series of ester glycosides combining water-soluble carotenoids crocetin and different sugars. It is one of the main active ingredients of saffron, including crocin -1, crocin -2, crocin -3, crocin-4 and crocetin.It is centrally acting antihypertensive and can prevent atherosclerosis and be of antithrombosis, antiplatelet aggregation, and anti myocardial ischemia.   | | Efficacy and effect | The traditional medicine believes that the stigma croci can dredge and activate the collaterals, remove blood stasis, eradicate depression and relieve swelling and pain. It is mainly used for the treatment of anxiety depression, chest distention, irregular menstruation, postpartum haemorrhage and traumatic injury. The main effective components are crocetin and crocin, which has many pharmacological activities, such as being anti-inflammatory and analgesic, antitumor, antidepressant, hypoglycemic and lowering blood pressure. Because the water solution of stigma croci is bright yellow with sweet smell, it is often used as a food additive and high-grade edible pigment, but also can be used as high dye for silk, cotton and wool products. In recent years, pharmacological researches indicate that stigma croci has good control effect for a variety of diseases, including cancer, coronary heart disease, atherosclerosis and hyperlipidemia. | | Pharmacological effects | Crocin has the effect of the anti-inflammation and treatment of soft tissue injury, gall liver protection, anti-tumor and other pharmacological effects. It is widely used in food, medicine, chemical industry and other industries. It is used in the treatment of patients with cardiovascular disease and fatty liver.with good medicinal value. | | Description | Crocin/Gardenia Extract is a Gardenia extract that contains crocin I, II, and III, and crocetin, among other compounds. | | Chemical Properties | Solid | | Uses | Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties. | | Definition | ChEBI: Crocin-1 is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol. It has a role as an antioxidant, a food colouring, a plant metabolite and a histological dye. It is a diester, a disaccharide derivative and a diterpenoid. It is functionally related to a beta-D-gentiobiosyl crocetin and a gentiobiose. | | General Description | A highly unsaturared diterpene dicarboxylic acid ester found in saffron. | | Biochem/physiol Actions | Crocin alleviates some ethanol-induced impairments of learning and prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP), a form of activity-dependent synaptic plasticity that may underly learning and memory. Related CNS effects are specific to the digentiobiose ester; crocetin glucose gentiobiose ester is half as potent, and the diglucose ester has no effect at all. |
| | CROCIN Preparation Products And Raw materials |
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