5-Hydroxymethylpyrrolidin-2-one

5-Hydroxymethylpyrrolidin-2-one Basic information

Product Name:	5-Hydroxymethylpyrrolidin-2-one
Synonyms:	D-PYROGLUTAMINOL;(-)-D-PYROGLUTAMOL;(R)-5-HYDROXYMETHYL-PYRROLIDIN-2-ONE;(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;(R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDONE;(R)-(-)-2-PYRROLIDONE-5-YL-METHANOL;5-(Hydroxymethyl)-2-pyrrolidinone
CAS:	66673-40-3
MF:	C5H9NO2
MW:	115.13
EINECS:	626-701-7
Product Categories:	Heterocycles;pharmacetical;Amino Acids 13C, 2H, 15N;Amides (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Amino Acids & Derivatives;Chiral Reagents
Mol File:	66673-40-3.mol

5-Hydroxymethylpyrrolidin-2-one Chemical Properties

Melting point	83-85 °C(lit.)
Boiling point	147-149 °C0.06 mm Hg(lit.)
density	1.1808 (rough estimate)
refractive index	-31 ° (C=5, EtOH)
Fp	147-149°C/0.06m
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Dimethylformamide, Water
pka	14.35±0.10(Predicted)
form	Crystalline Powder or Flakes
color	White to yellow
optical activity	[α]20/D 31°, c = 5 in ethanol
BRN	5728422
CAS DataBase Reference	66673-40-3(CAS DataBase Reference)

Safety Information

MSDS Information

5-Hydroxymethylpyrrolidin-2-one Usage And Synthesis

Chemical Properties	(R)-5-(Hydroxymethyl)-2-pyrrolidinone is White Powder
Uses	(R)-5-(Hydroxymethyl)-2-pyrrolidinone is a 2-pyrrolidone derivative for therapeutic use as prostanoid receptor agonist.
Uses	Serves as a building block in the synthesis of diphthamide.

5-Hydroxymethylpyrrolidin-2-one Preparation Products And Raw materials

Raw materials	Ethanol-->Hydrochloric acid-->Ethyl acetate-->Tetrahydrofuran-->Acetic acid-->Sodium borohydride-->L-Glutamic acid-->Lithium chloride-->D(-)-Glutamic acid
Preparation Products	D-Pyroglutamic acid-->(+)-D-PYROGLUTAMOL P-TOLUENESULFONATE

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