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| | 2'-O-Methylguanosine Basic information |
| Product Name: | 2'-O-Methylguanosine | | Synonyms: | 2'-OMe-G;2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one;2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one;2-azanyl-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]-3H-purin-6-one;2'-OMe Guanosine;2'-O-METHYLGUANOSINE;2'-O-Methyl-D-guanosine;2'-O-Methyl Guanosine, >=99% | | CAS: | 2140-71-8 | | MF: | C11H15N5O5 | | MW: | 297.27 | | EINECS: | | | Product Categories: | Nucleotides;Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleosides | | Mol File: | 2140-71-8.mol |  |
| | 2'-O-Methylguanosine Chemical Properties |
| Melting point | 227-231°C (dec.) | | density | 1.98±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Aqueous Base (Slightly), DMSO (Slightly), | | form | Powder | | pka | 9?+-.0.20(Predicted) | | color | White to Off-white | | InChI | InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1 | | InChIKey | OVYNGSFVYRPRCG-KQYNXXCUSA-N | | SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O | | CAS DataBase Reference | 2140-71-8(CAS DataBase Reference) |
| | 2'-O-Methylguanosine Usage And Synthesis |
| Description | 2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells. | | Chemical Properties | White Solid | | Uses | Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. | | Definition | ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group. |
| | 2'-O-Methylguanosine Preparation Products And Raw materials |
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