ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards ACT 080803

ACT 080803

ACT 080803 Basic information
Product Name:ACT 080803
Synonyms:ACT 080803;5-(4-Bromo-phenyl)-6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-ylamine;5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl);5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-amine;Macitentan N-Despropylaminosulfonyl Impurity;4-Pyrimidinamine, 5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-;Masitectan impurity;Macititan impurity 01
CAS:1433875-21-8
MF:C16H13Br2N5O2
MW:467.11
EINECS:
Product Categories:
Mol File:1433875-21-8.mol
ACT 080803 Structure
ACT 080803 Chemical Properties
Boiling point 607.5±65.0 °C(Predicted)
density 1.722±0.06 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka3.00±0.10(Predicted)
form Solid
color White to Off-White
Safety Information
MSDS Information
ACT 080803 Usage And Synthesis
UsesDespropylaminosulfonyl Macitentan is an impurity of Macitentan (M105005); a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension.
ACT 080803 Preparation Products And Raw materials
Macitentan Impurity 17 CarbaMic acid, N-[(propylaMino)sulfonyl]-, phenylMethyl ester Macitentan Impurity 13 Macitentan Impurity 2 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER Macitentan Impurity 4 5-(4-Bromophenyl)-4,6-dichloropyrimidine Macitentan Impurity 14 5-Bromo-2-chloropyrimidine Macitentan impurity A Macitentan Impurity 3 FORMAMIDINE HYDROCHLORIDE N,N-Dimethylaniline 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Macitentan Impurity 11 macitentan SulfaMide, N-[5-(4-broMophenyl)-6-(2-hydroxyethoxy)-4-pyriMidinyl]-N'-propyl- SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-
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