ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives Carboxylic acid halides INDOLE-3-GLYOXYLYL CHLORIDE

INDOLE-3-GLYOXYLYL CHLORIDE

INDOLE-3-GLYOXYLYL CHLORIDE Basic information
Product Name:INDOLE-3-GLYOXYLYL CHLORIDE
Synonyms:3-INDOLYLGLYOXALYL CHLORIDE;3-INDOLYL-GLYOXYL CHLORIDE;3-INDOLEGLYOXYLYL CHLORIDE;ALPHA-OXO-INDOLE-3-ACETYL CHLORIDE;INDOLE-3-GLYOXYLOYL CHLORIDE;INDOLE-3-GLYOXYLYL CHLORIDE;(2-(3-INDOLYL)-2-OXOACETYL) CHLORIDE;alpha-Oxoindoleacetyl chloride
CAS:22980-09-2
MF:C10H6ClNO2
MW:207.61
EINECS:245-362-2
Product Categories:Aromtatics, Heterocycles, Indole Derivatives, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Building Blocks;C10;Chemical Synthesis;Heterocyclic Building Blocks;Aromtatics;Heterocycles;Impurities;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Building Blocks;Indoles;Building Blocks;Heterocyclic Compounds
Mol File:22980-09-2.mol
INDOLE-3-GLYOXYLYL CHLORIDE Structure
INDOLE-3-GLYOXYLYL CHLORIDE Chemical Properties
Melting point 138 °C (dec.) (lit.)
Boiling point 413.9±37.0 °C(Predicted)
density 1.463±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka14.29±0.30(Predicted)
Sensitive Moisture Sensitive
BRN 147693
CAS DataBase Reference22980-09-2(CAS DataBase Reference)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-27-36/37/39-45
RIDADR UN 1759 8/PG 2
WGK Germany 3
HazardClass 8
PackingGroup II
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
INDOLE-3-GLYOXYLYL CHLORIDE Usage And Synthesis
Uses• ;Reactant for preparation of dual IGF-1R/SRC inhibitors1• ;Reactant for preparation of indolylglyoxylamides as a new class of antileishmanial agents2• ;Reactant for preparation of glyoxyl analogs of indole phytoalexins as anticancer agents3• ;Reactant for diastereoselective synthesis of heptacyclic core of dragmacidin E4• ;Reactant for preparation of benzoylmethylpyrrolopyridinylethanedione as HIV-1 inhibitor5• ;Reactant for preparation of fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D16
UsesINDOLE-3-GLYOXYLYL CHLORIDE is an indole derivative used in the preparation of reagents for chemiluminescent enzyme immunoassay. It is an impurity in the manufacture of tryptamines and related compounds.
Uses
  • Reactant for preparation of dual IGF-1R/SRC inhibitors
  • Reactant for preparation of indolylglyoxylamides as a new class of antileishmanial agents
  • Reactant for preparation of glyoxyl analogs of indole phytoalexins as anticancer agents
  • Reactant for diastereoselective synthesis of heptacyclic core of dragmacidin E
  • Reactant for preparation of benzoylmethylpyrrolopyridinylethanedione as HIV-1 inhibitor
  • Reactant for preparation of fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1
INDOLE-3-GLYOXYLYL CHLORIDE Preparation Products And Raw materials
Preparation ProductsTryptophol-->Methyl indolyl-3-glyoxylate-->INDOLE-3-(N,N-DIMETHYL)GLYOXYLAMIDE-->1-(1H-Indol-3-yl)-2-morpholin-4-yl-2-oxoethanone
indomethacin farnesil INDOLE-2,5-DICARBOXYLIC ACID 2-ETHYL ESTER 5-METHYL ESTER 3-(3-Indolyl)-2-oxopropanoic acid Methyl 1H-indole-2-carboxylate INDOLE-3-ACETIC ACID ETHYL INDOLE-2-ACETATE 3-formyl-1H-Indole-4-carboxylic acid methyl ester Dimethyl indole-2,6-dicarboxylate Ethyl 1H-indole-4-carboxylate ETHYL INDOLE-5-CARBOXYLATE Methyl indole-3-carboxylate 2-(1H-indol-3-yl)acetaldehyde 2-(7-methyl-1H-indol-3-yl)-2-oxoacetyl chloride (1-BENZYL-3-CHLOROOXALYL-2-ETHYL-1H-INDOL-4-YLOXY)-ACETIC ACID METHYL ESTER (1-NAPHTHALEN-2-YL-1H-INDOL-3-YL)-OXO-ACETYL CHLORIDE 7-CHLORO-ALPHA-OXO-1H-INDOLE-3-ACETYL CHLORIDE AKOS BC-1933 7-METHOXY-ALPHA-OXO-1H-INDOLE-3-ACETYL CHLORIDE
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