2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Chemical Properties
Boiling point
369.6±27.0 °C(Predicted)
density
1.547±0.06 g/cm3(Predicted)
pka
4.32±0.11(Predicted)
Safety Information
MSDS Information
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Usage And Synthesis
Uses
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
Synthesis
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is prepared by reacting 4-Ethyl-α,α-dimethylbenzeneacetic acid with N-Iodosuccinimide in Acetic acid for 2h.
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Preparation Products And Raw materials
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