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| | Methyl 2,3-dichloropropionate Basic information |
| Product Name: | Methyl 2,3-dichloropropionate | | Synonyms: | METHYL 2,3-DICHLOROPROPIONATE;METHYL-A,B-DICHLOROPROPIONATE;METHYL ALPHA,BETA-DICHLOROPROPIONATE;2,3-DICHLOROPROPIONIC ACID METHYL ESTER;2,3-dichloro-propanoicacimethylester;Methyl 2,3-dichloropropanoate;Propionic acid, 2,3-dichloro-, methyl ester;METHYL-2,3-DICHLOROPROPIONATE, 1000MG, N EAT | | CAS: | 3674-09-7 | | MF: | C4H6Cl2O2 | | MW: | 157 | | EINECS: | 222-940-2 | | Product Categories: | Alpha Sort;M;MAlphabetic;META - METH;Volatiles/ Semivolatiles | | Mol File: | 3674-09-7.mol |  |
| | Methyl 2,3-dichloropropionate Chemical Properties |
| Boiling point | 52-55 °C/2 mmHg (lit.) | | density | 1.325 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.453(lit.) | | Fp | 145 °F | | storage temp. | Store below +30°C. | | solubility | Soluble in ether, acetone, ethanol. | | form | neat | | color | Colorless to Almost colorless | | BRN | 1701891 | | InChI | InChI=1S/C4H6Cl2O2/c1-8-4(7)3(6)2-5/h3H,2H2,1H3 | | InChIKey | OFHMODDLBXETIK-UHFFFAOYSA-N | | SMILES | C(OC)(=O)C(Cl)CCl | | CAS DataBase Reference | 3674-09-7(CAS DataBase Reference) | | NIST Chemistry Reference | Propanoic acid, 2,3-dichloro-, methyl ester(3674-09-7) | | EPA Substance Registry System | Propanoic acid, 2,3-dichloro-, methyl ester (3674-09-7) |
| | Methyl 2,3-dichloropropionate Usage And Synthesis |
| Chemical Properties | clear colorless to slightly yellow liquid | | Uses | Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate. | | Application | Methyl 2,3-Dichloropropanoate is a useful reagent in preparation of oxidative fragmentation and coupling of catharanthine analogs to vindoline. | | Synthesis | Preparation of Methyl 2,3-dichloropropanoate:
Methyl acrylate (2366 g, 27.5 mol) and dimethylformamide (DMF) (40 g, 0.55 mol) was placed in a 3-liter three necked flask fitted with a stirrer, thermometer, inlet tube and gas trap. Chlorine (950 g, 0.48 mol) was passed into the methyl acrylate rapidly over a period of ten hours while the temperature was kept below 40°C. Reaction progress was monitored by gas chromatography (GC). When it seemed that 50 percent of chlorine was consumed, the reaction was stopped. The reaction mass was taken for distillation to separate methylacrylate and Methyl 2,3-dichloropropanoate. The contents were subjected to vacuum distillation. Methyl 2,3-dichloropropanoate was collected distilling at 70°C with 15mm.Yield (%):77.2, Purity (%) = 98. |
| | Methyl 2,3-dichloropropionate Preparation Products And Raw materials |
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