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| (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Basic information |
Product Name: | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol | Synonyms: | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Dinaciclib (SCH727965);2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-;Dinaciclib, >=98%;DINACICLIB (SCH727965);SCH 727965;(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol;(S)-3-(((3-Ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methy;Dinaciclib (SCH727965), ≥98%;CS-213 | CAS: | 779353-01-4 | MF: | C21H28N6O2 | MW: | 396.49 | EINECS: | 214-589-6 | Product Categories: | Inhibitors | Mol File: | 779353-01-4.mol | |
| (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Chemical Properties |
Melting point | >78oC (dec.) | density | 1.33 | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | solubility | Chloroform (Slightly), Methanol (Slightly) | pka | 15.15±0.10(Predicted) | form | Solid | color | White to Light Beige | Stability: | Hygroscopic | CAS DataBase Reference | 779353-01-4 |
| (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Usage And Synthesis |
Uses | Dinaciclib is a potent and selective inhibitor of cyclin-dependent kinases which is undergoing development as oncology therapeutics. | Definition | ChEBI: 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol is a pyrazolopyrimidine. | Biological Activity | dinaciclib is a potent cyclin-dependent kinase (cdk) inhibitor with ic50s for cdk2, cdk5, cdk1 and cdk9 at 1 nm, 1 nm, 3 nm, and 4 nm, respectively. [1] it is in phase i or ii | target | CDK2 | storage | Store at -20°C | references | [1]parry d., et al. (2010). dinaciclib (sch 727965), a novel and potent cyclin-dependent kinase inhibitor. mol cancer ther (9): 2344- 2353. [2]martin, m. p., et al. (2013). cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. acs chemical biology 8 (11): 2360–5. [3]payton m., et al. (2006). discovery and evaluation of dual cdk1 and cdk2 inhibitors. cancer res 66: 4299-4308. |
| (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Preparation Products And Raw materials |
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