ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound 2-Amino-5-bromo-3-(hydroxymethyl)pyridine

2-Amino-5-bromo-3-(hydroxymethyl)pyridine

2-Amino-5-bromo-3-(hydroxymethyl)pyridine Basic information
Product Name:2-Amino-5-bromo-3-(hydroxymethyl)pyridine
Synonyms:(2-AMINO-5-BROMO-3-PYRIDINYL)METHANOL;(2-AMINO-5-BROMO-PYRIDIN-3-YL)-METHANOL;2-Amino-5-bromopyridine-3-methanol;2-Amino-5-bromo-3-(hydroxymethyl)pyridine;2-Amino-5-Bromo-3-(Hydroxymeth;2-Amino-5-bromo-3-pyridinemethanol;2-broMo-4-ethoxypyriMidine;2-AMino-3-hydroxyMethyl-5-broMopyridine
CAS:335031-01-1
MF:C6H7BrN2O
MW:203.04
EINECS:
Product Categories:Heterocycle-Pyridine series;Aromatics;Hydroxymethyl's;Pyridines;Pyridine;Heterocycles;pharmacetical;Pyridine series;Heterocyclic Compounds
Mol File:335031-01-1.mol
2-Amino-5-bromo-3-(hydroxymethyl)pyridine Structure
2-Amino-5-bromo-3-(hydroxymethyl)pyridine Chemical Properties
Melting point 137-140°C
Boiling point 343.5±37.0 °C(Predicted)
density 1.766±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Acetone, Ethyl Acetate, Methanol
pka13.16±0.10(Predicted)
form Solid
color Off-white to yellow
CAS DataBase Reference335031-01-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
HazardClass IRRITANT
HS Code 2933399990
MSDS Information
2-Amino-5-bromo-3-(hydroxymethyl)pyridine Usage And Synthesis
Uses2-Amino-5-bromo-3-(hydroxymethyl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis2-Amino-5-bromo-3-(hydroxymethyl)pyridineBromine (8.4 mL, 189.4 mmol) was added dropwise over 1 hour to a solution of 2- amino-3-(hydroxymethyl)pyridine (19.6 g, 157.8 mmol) in acetic acid (350 mL) at room temperature. The reaction mixture was then stirred overnight. After concentration to dryness, the residue was partitioned between a saturated solution of potassium carbonate (300 mL) and ethyl acetate (200 ml_). The aqueous layer was separated and extracted with ethyl acetate (2 x 200 ml_). The combined organic phases were washed with a saturated solution of sodium chloride (200 ml_), dried over sodium sulfate, filtered and concentrated to dryness. After trituration of the residue in pentane, the title product was obtained as a yellow solid (27.0 g, 84%).
2-Amino-5-bromo-3-(hydroxymethyl)pyridine Preparation Products And Raw materials
Raw materials(2-Aminopyridin-3-yl)methanol
2-AMINO-5-BROMO-4-METHYL NICOTINIC ACID HCL 2-Amino-5-bromonicotinic acid methyl 5-bromo-2-morpholinonicotinate 5-bromo-2-piperidinonicotinic acid 2-Amino-5-bromo-3-(hydroxymethyl)pyridine IFLAB-BB F2124-0031 methyl 5-bromo-2-piperidinonicotinate tert-Butyl 4-[5-bromo-3-(methoxycarbonyl)pyridin-2-yl]piperazine-1-carboxylate (5-BROMO-PYRIDIN-3-YL)-METHANOL ETHYL 2-AMINO-5-BROMONICOTINATE 2-Amino-5-bromopyridine Methyl 2-amino-5-bromonicotinate 2-Amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide IFLAB-BB F2124-0032 5-BROMO-6-METHYL-2-METHYLAMINO-NICOTINIC ACID
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