Amidinothiourea

Amidinothiourea Basic information

Product Name:	Amidinothiourea
Synonyms:	GUANYLTHIOUREA;2-IMINO-4-THIOBIURET;[(AMINOCARBOTHIOYL)AMINO]METHANIMIDAMIDE;AMINOIMINOETHYL THIOUREA;AMIDINOTHIOUREA;ZERENEX ZX006496;1-amidino-2-thiourea;Guanphenisin BP
CAS:	2114-02-5
MF:	C2H6N4S
MW:	118.16
EINECS:	218-308-0
Product Categories:	Pharmaceutical Intermediates;Famotidine
Mol File:	2114-02-5.mol

Amidinothiourea Chemical Properties

Melting point	171-173 °C(lit.)
Boiling point	231.2±23.0 °C(Predicted)
density	1.301 (estimate)
refractive index	1.5605 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	11.89±0.70(Predicted)
form	Crystalline Powder or Crystals
color	White to off-white
PH	8.87 at 24.1℃ and 10g/L
Water Solubility	7 g/100 mL (20 ºC)
BRN	1756620
InChIKey	OKGXJRGLYVRVNE-UHFFFAOYSA-N
LogP	1.8 at 30℃ and pH7.86
CAS DataBase Reference	2114-02-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-37/39-24/25-23
RIDADR	2811
WGK Germany	3
RTECS	YR8250000
PackingGroup	III
HS Code	29309090
Toxicity	mouse,LD50,intraperitoneal,1440mg/kg (1440mg/kg),Pharmaceutical Chemistry Journal Vol. 30, Pg. 181, 1996.

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

Amidinothiourea Usage And Synthesis

Chemical Properties	white to off-white crystals or crystalline powder
Uses	2-Imino-4-thiobiuret is used in the design and synthesis of guanylthiourea derivatives which are potential inhibitors of plasmodium falciparum dihydrofolate reductase enzyme. 2-Imino-4-thiobiuret is also used as a reagent in recyclization reactions of N-arylmaleimides with polynucleophilic compounds.

Amidinothiourea Preparation Products And Raw materials

Raw materials	Hydrogen Sulfide-->Dicyandiamide-->1,4-Benzoquinone dioxime-->Dithiobiuret
Preparation Products	Famotidine-->(S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride-->3-(2-Guanidino-thiazol-4-yl-methylthio)-propionitrile-->2-(4-(CHLOROMETHYL)THIAZOL-2-YL)GUANIDINE-->ethyl 2-guanidino-4-methylthiazole-5-carboxylate-->N-[4-(3-Thienyl)-1,3-thiazol-2-yl]guanidine-->N-(4-Oxo-4,5-dihydro-1,3-thiazol-2-yl)guanidine

N-Aminothiourea AKOS BBS-00002960 N-METHYLTHIOUREA Amidinothiourea N,N'-Diethylthiourea Allylthiourea AKOS BBS-00002959 THIOUREA AKOS BBS-00002958 1-PHENYL-2-THIOUREA usafb-45 3-(ISOPROPYLIDENEAMINOAMIDINO)-1-PHENYLTHIOUREA Ethylene thiourea 1-NITRO 3-(N-ALLYL THIOCARBAMOYL) GUANIDINE N-(4-OXO-3,4,5,6,7,8-HEXAHYDRO-2-QUINAZOLINYL)THIOUREA 1-NITRO 3-(N-PHENYL THIOCARBAMOYL) GUANIDINE 1,3-Diphenyl-2-thiourea N-(6-OXO-5-PROPIONYL-1,6-DIHYDRO-2-PYRIMIDINYL)THIOUREA

Email:[email protected] [email protected]

Copyright © 2024 Mywellwork.com All rights reserved.