ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives Carboxylic acid esters and derivatives Ethyl 6-chloronicotinate

Ethyl 6-chloronicotinate

Ethyl 6-chloronicotinate Basic information
Product Name:Ethyl 6-chloronicotinate
Synonyms:3-Pyridinecarboxylic acid, 6-chloro-, ethyl ester;ETHYL 6-CHLORONICOTINATE[FOR TAZAROTENE];Ethyl 6-chloropyridine-3-carboxylate;ETHYL 2-CHLOROPYRIDINE-5-CARBOXYLATE;Ethyl 6-chloronicoti;2-Chloro-5-pyridinecarboxylicacid ethylester;Ethyl6-chloronicotinate,97%;Ethyl 2-chloropyridine-3-carboxylate, 6-Chloronicotinic acid ethyl ester
CAS:49608-01-7
MF:C8H8ClNO2
MW:185.61
EINECS:610-463-6
Product Categories:Building Blocks;C7 to C18;C8 to C9;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Esters;Pyridines;Heterocycle-Pyridine series;carboxylic ester| alkyl chloride
Mol File:49608-01-7.mol
Ethyl 6-chloronicotinate Structure
Ethyl 6-chloronicotinate Chemical Properties
Melting point 26-30 °C(lit.)
Boiling point 98 °C
density 1.245±0.06 g/cm3(Predicted)
refractive index 1.522
Fp >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka-1.95±0.10(Predicted)
form Solid
color Colourless to Off-White Oil
BRN 4742175
InChIKeyILDJJTQWIZLGPO-UHFFFAOYSA-N
CAS DataBase Reference49608-01-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Ethyl 6-chloronicotinate Usage And Synthesis
Chemical PropertiesWhite to light yellow solid or colorless to yellow liquid
UsesEthyl 6-chloronicotinate is a nicotinic acid derivative used in the preparation of potent H3 receptor antagonists.
UsesEthyl 6-chloropyridine-3-carboxylate (Ethyl 6-chloronicotinate) may be used in the preparation of ethyl 5-{[5-(1H-benzimidazol-2-yl)pyridin-2-yl]ethynyl}pyridine-2-carboxylate by reacting with 2-[6-(ethynyl)pyridin-3-yl]-1H-benzimidazole under microwave irradiation.
General DescriptionEthyl 6-chloropyridine-3-carboxylate (Ethyl-6-chloronicotinate, E-6-ClN) undergoes direct amidation on reacting with benzylamine in the presence lanthanum trifluoromethanesulfonate La(OTf)3. The structural and physicochemical properties of E-6-ClN have been investigated based on its spectroscopic data, time-dependent density functional theory and density of state diagrams.
Ethyl 6-chloronicotinate Preparation Products And Raw materials
Preparation Products6-MORPHOLINONICOTINONITRILE-->Tazarotene-->6-MORPHOLINONICOTINOHYDRAZIDE-->(6-MORPHOLINO-3-PYRIDINYL)METHANOL-->[6-(1-PYRROLIDINYL)-3-PYRIDINYL]METHANOL-->Pyridine, 5-(bromomethyl)-2-chloro- (9CI)-->6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester-->3-Pyridinecarboxaldehyde, 6-(2-methyl-1H-imidazol-1-yl)--->6-(3,3,3-Trifluoropropoxy)nicotinic acid
Ethyl nicotinate Trinexapac-ethyl Ethanol Ethyl formate Tris(trimethylsilyl)phosphate Ethylparaben Ethyl chloroformate Ethyl isonicotinate ISOXADIFEN-ETHYL Ethyl acetate Ethyl propiolate Ethyl 5-bromonicotinate Ethyl acrylate Methyl acrylate RESMETHRIN Ethyl 2-chloroacetoacetate Ethyl chloroacetate Ethyl cyanoacetate
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