(S)-(-)-Indoline-2-carboxylic acid

(S)-(-)-Indoline-2-carboxylic acid Basic information

Product Name:	(S)-(-)-Indoline-2-carboxylic acid
Synonyms:	(R)-1H-INDOLE-2-CARBOXYLIC ACID;(R)-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID;(R)-(+)-2,3-DIHYDROINDOLE-2-CARBOXYLIC ACID;Perindopril Intermediate;(2S)-indoline-2-carboxylic acid;(2S)-2,3-dihydro-1H-Indole-2-carboxylic acid;(S)-Indoline-2-Carboxylic;1H-Indole-2-carboxylicacid,2,3-dihydro-,(2S)-(9CI)
CAS:	79815-20-6
MF:	C9H9NO2
MW:	163.17
EINECS:	410-860-2
Product Categories:	Heterocycle-Indole series;Chiral Compound;Indoles;Asymmetric Synthesis;Chiral Catalysts, Ligands, and Reagents;Proline-Based Organocatalysts;PYRROLE;Indoles and derivatives;pharmacetical;chiral;PERINDOPRIL;(intermediate of perindopril);Pharmaceutical Intermediates
Mol File:	79815-20-6.mol

(S)-(-)-Indoline-2-carboxylic acid Chemical Properties

Melting point	177 °C (dec.)(lit.)
alpha	-112.5 º (c=1, 1N HCl)
Boiling point	290.25°C (rough estimate)
density	1.2021 (rough estimate)
refractive index	-116 ° (C=1, 2mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Water Solubility	Slightly soluble in water
pka	2.04±0.20(Predicted)
form	Powder
color	Beige to brown
optical activity	[α]20/D 114°, c = 1 in 1 M HCl
InChIKey	QNRXNRGSOJZINA-QMMMGPOBSA-N
CAS DataBase Reference	79815-20-6(CAS DataBase Reference)

Safety Information

MSDS Information

(S)-(-)-Indoline-2-carboxylic acid Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	Catalyst for enantioselective cyclopropanations.

(S)-(-)-Indoline-2-carboxylic acid Preparation Products And Raw materials

Raw materials	Wy 44221-->1H-Indole-2-carboxylic acid, 1-acetyl-2,3-dihydro-, Methyl ester, (2S)--->(R)-(+)-Indoline-2-carboxylic acid-->L-2-Bromophenylalanine-->1H-Indole-2-carboxylicacid,2,3-dihydro-,methylester,(2S)-(9CI)-->2-Chloro-L-phenylalanine-->2-Bromobenzyl bromide-->Indole-2-carboxylic acid
Preparation Products	Perindopril-->(S)-(+)-2-INDOLINEMETHANOL

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