ChemicalBook Product Catalog Chemical Reagents Organic reagents Boric acid 2-Trifluoromethylphenylboronic acid

2-Trifluoromethylphenylboronic acid

2-Trifluoromethylphenylboronic acid Basic information
Product Name:2-Trifluoromethylphenylboronic acid
Synonyms:ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLUENEBORONIC ACID;ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYLBORONIC ACID;AKOS BRN-0242;RARECHEM AH PB 0094;O-TRIFLUOROMETHYLPHENYLBORONIC ACID;2-benzotrifluorideboronic acid;B-[2-(TrifluoroMethyl)phenyl]boronic acid;2-(TrifluoroMethyl)phenylboronic Acid 
CAS:1423-27-4
MF:C7H6BF3O2
MW:189.93
EINECS:640-203-7
Product Categories:Aryl Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Substituted Boronic Acids;Boronic Acids & Esters;Phenyls & Phenyl-Het;Aryl;Boronic acid;Organoborons;Boronic Acids & Esters;Phenyls & Phenyl-Het;Boronic Acids;Boronic Acids and Derivatives;B (Classes of Boron Compounds);Boronic Acids;Boronic acid series;blocks;BoronicAcids;FluoroCompounds;Boronate Ester;Potassium Trifluoroborate;Monosubstituted Aryl Boronic Acids;Organometallic Reagents
Mol File:1423-27-4.mol
2-Trifluoromethylphenylboronic acid Structure
2-Trifluoromethylphenylboronic acid Chemical Properties
Melting point 111-114 °C (lit.)
Boiling point 274.5±50.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility slightly sol. in Methanol
pka8.11±0.58(Predicted)
form powder to crystal
color White to Almost white
BRN 2974465
InChIKeyJNSBEPKGFVENFS-UHFFFAOYSA-N
CAS DataBase Reference1423-27-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 37/39-26-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29163990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
2-Trifluoromethylphenylboronic acid Usage And Synthesis
Chemical Propertieswhite to light beige crystalline powder
Uses2-(Trifluoromethyl)phenylboronic acid can be used as a reactant:
  • In Suzuki-coupling reactions to prepare 2-trifluoromethyl aryl or heteroaryl derivatives.
  • To synthesize 4-(2-trifluoromethyl)phenylpyrrolo[2,3-d]pyrimidine as a potential antagonist of corticotropin-releasing hormone.
  • To prepare 2-nitro-6-(trifluoromethyl)phenylboronic acid by nitration reaction.

Usessuzuki reaction
Uses2-Trifluoromethylphenylboronic Acid is a reagent in the preparation of potent inhibitors of human uric acid transporter 1 (hURAT1).
2-Trifluoromethylphenylboronic acid Preparation Products And Raw materials
Preparation ProductsNIH-12848-->2-Trifluoromethyl-6-nitrophenylboronic acid
2-Bromo-5-(trifluoromethyl)phenylboronic acid 2-BROMO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID 4-Tolylboronic acid (Trifluoromethyl)trimethylsilane ((4S,5S)-(-)-O-[1-BENZYL-1-(5-METHYL-2-PHENYL-4,5-DIHYDROOXAZOL-4-YL)-2-PHENYLETHYL]-DICYCLOHEXYL-PHOSPHINITE)(1,5-COD)IRIDIUM (I) TETRAKIS(3,5-BIS(TRIFLUOROMETHYL)PHENYLBORATE 2-Methyl-4-(trifluoromethyl)phenylboronic acid Ethyl 2-(Chlorosulfonyl)acetate 2-Chloro-3-trifluoromethylphenylboronic acid Ascoric Acid 4-ISOPROPOXY-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID 2-Chloro-4-trifluoromethylphenylboronic acid Trifluoromethyl 2-Methyl-3-trifluoromethyl-phenylboronic acid 2,4-Bis(trifluoromethyl)phenylboronic acid 3,5-Dimethylphenylboronic acid 4-HYDROXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID Lithium triflate 5-(4-methoxy)Benzyloxy-3-trifluoromethylphenylboronic acid
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