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| | Diisopropylammonium dichloroacetate Basic information |
| | Diisopropylammonium dichloroacetate Chemical Properties |
| Melting point | 119-121° | | RTECS | AG6475000 | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Crystalline Powder | | color | White | | Merck | 14,3197 | | Stability: | Hygroscopic | | InChI | InChI=1S/C6H15N.C2H2Cl2O2/c1-5(2)7-6(3)4;3-1(4)2(5)6/h5-7H,1-4H3;1H,(H,5,6) | | InChIKey | ILKBHIBYKSHTKQ-UHFFFAOYSA-N | | SMILES | C(O)(=O)C(Cl)Cl.CC(NC(C)C)C | | CAS DataBase Reference | 660-27-5 | | EPA Substance Registry System | Acetic acid, dichloro-, compd. with N-(1-methylethyl)-2-propanamine (1:1) (660-27-5) |
| TSCA | Yes | | HS Code | 2921199990 | | Toxicity | LD50 orally in mice: 1700 mg/kg (Kraushaar) |
| | Diisopropylammonium dichloroacetate Usage And Synthesis |
| Description | Diisopropylammonium dichloroacetate is a hepatoprotective drug that improves the energy metabolism of hepatocytes, promotes the regeneration of injured hepatocytes, increases the rate of tissue cell respiration and oxygen respiration, and reduces the accumulation of fat in the liver. It is mainly used clinically for the treatment of fatty liver, intrahepatic cholestasis, and general liver dysfunction. It is also used in the treatment of acute and chronic hepatitis, hepatomegaly, and early cirrhosis. | | Chemical Properties | White or off-white loose mass or powder, slightly bitter, easily soluble in water, ethanol or chloroform, slightly soluble in ether. | | History | In the 1950s, the compound diisopropylammonium dichloroacetate (DIPA) was used in the synthesis of methylated derivatives of a purportedly naturally occurring B vitamin (pangamic acid; dgluconodimethylaminoacetate). Anecdotal clinical reports appeared claimingefficacy in various metabolic and cardiovascular disorders from pharmaceuticalmixtures of pangamic acid and DIPA. In 1970,DCA was identified as themetabolically active moiety of DIPA(Stacpoole & Felts,1970) and it has beenused thereafter almost exclusively as the sodium salt. | | Uses | Diisopropylammonium dichloroacetate (DIPA) is known to produce a significant and prolonged hypoglycemic effect in alloxan-diabetic but not in normal rats.
Diisopropylamine 2,2-Dichloroacetate is used in the treatment of antituberculosis drugs-induced liver injury. | | Definition | ChEBI: Diisopropylamine dichloroacetate is an organohalogen compound and a carboxylic acid. | | Mode of action | The mechanism of action of diisopropyl dichloroacetate is to enhance the fluidity of hepatocyte membranes by promoting sequential methylation of membrane phospholipids, to increase the activity of Na+-K+-ATPase, which is the main driving force of bile secretion and flow; to promote the functional repair of damaged hepatocytes, to improve the respiratory function and oxygen utilization of tissue cells, to increase the metabolic activity of fatty acids, to accelerate the oxidation of fatty acids, and to create conditions for the recovery of liver function. |
| | Diisopropylammonium dichloroacetate Preparation Products And Raw materials |
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