Cefozopran

Cefozopran Basic information

Product Name:	Cefozopran
Synonyms:	CEFOZOPRAN;sce2787;SCE2787;SCE 2787;Cefozopran(SCE 2787);1-[[(6R,7R)-7-[[(2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-imidazo[1,2-b]pyridazinium hydroxide inner salt;1-[[(6R,7R)-7-[[2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridazinium Inner Salt;Firstci;SCE-1787
CAS:	113359-04-9
MF:	C19H17N9O5S2
MW:	515.52
EINECS:	601-249-3
Product Categories:	Antibacterial;Intermediates & Fine Chemicals;Cefozopran Hydrochloride and its intermediates;Pharmaceuticals
Mol File:	113359-04-9.mol

Cefozopran Chemical Properties

Melting point	>300°C
storage temp.	Store at -20°C
solubility	Soluble in DMSO
CAS DataBase Reference	113359-04-9(CAS DataBase Reference)

Safety Information

MSDS Information

Cefozopran Usage And Synthesis

Chemical Properties	White To Pale-Yellow Powder
Uses	Antibacterial
Definition	ChEBI: Cefozopran is a fourth-generation cephalosporin antibiotic having imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. It is a cephalosporin, a member of thiadiazoles and an imidazopyridazine.
Antimicrobial activity	An aminothiazole cephalosporin formulated as the hydrochloride. Activity is similar to that of ceftazidime, but it is more active against methicillin-susceptible staphylococci (MIC 1 mg/L). Representative MICs against Gram-negative species are: Esch coli 0.25 mg/L; K. pneumoniae 1 mg/L; Ps. aeruginosa 1–8 mg/L. Activity against Acinetobacter spp., Sten. maltophilia and B. fragilis group is poor. A 20-min infusion of 1.5 g achieved a plasma concentration of around 125 mg/L at the end of infusion. Almost 90% of the dose was excreted in the urine over 24 h. The mean terminal half-life was around 2 h. Adverse reactions appear to be typical of those of other group 6 cephalosporins. It is available in Japan.

Cefozopran Preparation Products And Raw materials

Raw materials

Ethyl acetate-->Dichloromethane-->Hexane-->Trifluoroacetic acid-->Phosphorus pentachloride-->Potassium iodide-->2-Butanone-->Formamide-->2-Mercapto-5-methyl-1,3,4-thiadiazole-->Pyridazine

Acetyl-resveratrol 5-AMINO-3-ETHYL-1,2,4-THIADIAZOLE N-Acetyl-L-cysteine Acetylacetone Cefozopran Cefazolin Acetamide Cefozopran hydrochloride DIACETAMIDE ALTRENOGEST Acetyl chloride 6-Aminocaproic acid 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Acetyl coenzyme A sodium salt Thioacetamide Tris(hydroxymethyl)aminomethane AMINO ACIDS N,N-Dimethylacetamide

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