ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives Acyclic carboxylic acid Benzilic acid

Benzilic acid

Benzilic acid Basic information
Product Name:Benzilic acid
Synonyms:BENZILIC ACID extrapure;Benzilic acidDiphenylglycolic acid;TrospiuM Chloride Related CoMpound A;Trospium Chloride Related Compound A (20 mg) (Benzilic Acid) (Internationally Restricted Sales Item);BENZILIC ACID FOR SYNTHESIS 1 KG;BENZILIC ACID FOR SYNTHESIS 250 G;Benzeneacetic acid,a-hydroxy-a-phenyl-;Trospium Chloride Related Compound A (20 mg) (Benzilic Acid) (International Restricted Sales Item)
CAS:76-93-7
MF:C14H12O3
MW:228.25
EINECS:200-993-2
Product Categories:Pharmaceutical Intermediates;Organics;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
Mol File:76-93-7.mol
Benzilic acid Structure
Benzilic acid Chemical Properties
Melting point 149-151 °C(lit.)
Boiling point 180 °C
density 1.28
refractive index 1.5805 (estimate)
Fp 180°C/22mm
storage temp. Store below +30°C.
solubility 1.41g/l (experimental)
pkapKa (25°): 3.036
form Powder
color White to cream-white
Water Solubility 1.41 g/L (25 ºC)
Merck 14,1080
BRN 521402
Stability:Stable. Incompatible with strong oxidizing agents. Combustible.
LogP2.300
CAS DataBase Reference76-93-7(CAS DataBase Reference)
NIST Chemistry ReferenceBenzeneacetic acid, «alpha»-hydroxy-«alpha»-phenyl-(76-93-7)
EPA Substance Registry SystemBenzilic acid (76-93-7)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38-20/21/22
Safety Statements 36-36/37/39-26
WGK Germany 3
RTECS DD2064000
TSCA Yes
HS Code 29181980
Hazardous Substances Data76-93-7(Hazardous Substances Data)
ToxicityLD50 orl-mus: 2 g/kg AIPTAK 116,154,58
MSDS Information
ProviderLanguage
2-Hydroxy-2,2-diphenylacetic acid English
SigmaAldrich English
ALFA English
Benzilic acid Usage And Synthesis
Chemical Propertieswhite powder
UsesBenzilic Acid is an impurity of Trospium (T892800), a tropine derivative with anticholinergic activity and a antiispasmodic agent.
DefinitionChEBI: Benzilic acid is a 2-hydroxy monocarboxylic acid.
Synthesis Reference(s)The Journal of Organic Chemistry, 29, p. 1631, 1964 DOI: 10.1021/jo01029a509
Safety ProfileModerately toxic by subcutaneousroute. Slightly toxic by ingestion. When heated todecomposition it emits acrid smoke and irritating vapors.
Purification MethodsCrystallise benzilic acid from *benzene (ca 6mL/g), or hot H2O. [Beilstein 10 IV 1256.]
2,2-Diphenylacetic acid Potassium hydrogen phthalate Benzilic acid Ethyl glycolate 2-Hydroxyphenylacetic acid Diphenyl ether Stearic acid Diglycolamide laurate POLY(2-HYDROXYACETIC ACID) Chlorodiphenylphosphine 3,4-Dihydroxyphenylacetic acid Dichlorodiphenylsilane phosphoric acid Bis(2-ethylhexyl) phthalate CHLOROPHOSPHONAZO III 1,5-Diphenylcarbazide Glycolic acid Citric acid
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