[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Basic information
Uses
Product Name:[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid
Synonyms:Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA;Fmoc-PEG2-acetic acid;{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC);Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem;1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID;8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID;8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID
CAS:166108-71-0
MF:C21H23NO6
MW:385.41
EINECS:200-111-8
Product Categories:peg;166108-71-0
Mol File:166108-71-0.mol
[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Structure
[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Chemical Properties
Melting point 90-92℃
Boiling point 631.4±45.0 °C(Predicted)
density 1.265±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka3.40±0.10(Predicted)
form Crystalline Powder
color White
InChIKeyXQPYRJIMPDBGRW-UHFFFAOYSA-N
CAS DataBase Reference166108-71-0(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29189900
MSDS Information
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SigmaAldrich English
[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Usage And Synthesis
Uses[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is a hydrophilic, heterobifunctional spacer.
DescriptionFmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical PropertiesWhite solid
UsesHydrophillic spacer group.
Uses8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.
[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Ethyl 2-(Chlorosulfonyl)acetate Acetic anhydride DIETHOXYMETHANE 6-Aminocaproic acid Ethoxyquin Glycine FMOC-THR(TBU)-OL 4-Aminophenylacetic acid 9-Fluorenylmethyl chloroformate Fmoc-Phe-OH Iminodiacetic acid 2-Aminothiazole-4-acetic acid Nitrilotriacetic acid N-(9-Fluorenylmethoxycarbonyloxy)succinimide Phenylacetic acid Ethoxyethyne [2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL]-CARBAMIC ACID 9H-FLUOREN-9-YLMETHYL ESTER

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