Tetrakis(hydroxymethyl)phosphonium chloride

Tetrakis(hydroxymethyl)phosphonium chloride Basic information
Product Name:Tetrakis(hydroxymethyl)phosphonium chloride
Synonyms:TETRA(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE;TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE;tetramethylolphosphonium chloride;nci-c55061;Phosphonium,tetrakis(hydroxymethyl)-,chloride;pyrosettkc;tetrakis-(hydroxymethyl)fosfoniumchlorid;tetrakis(hydroxymethyl)phosphochloride
CAS:124-64-1
MF:C4H12ClO4P
MW:190.56
EINECS:204-707-7
Product Categories:texitile auxiliary agents;Phosphonium Compounds;Greener Alternatives: Catalysis;Phase Transfer Catalysts;Phosphonium Salts;Phosphonium Salts
Mol File:124-64-1.mol
Tetrakis(hydroxymethyl)phosphonium chloride Structure
Tetrakis(hydroxymethyl)phosphonium chloride Chemical Properties
Melting point 154°C
Boiling point 115°C/760mmHg
density 1.341 g/mL at 25 °C
vapor pressure 0Pa at 25℃
refractive index n20/D 1.512
pka6.05[at 20 ℃]
form Solution
color Clear light pink or yellow-green
Water Solubility >=10 g/100 mL at 20 ºC
BRN 3631669
InChIKeyAKXUUJCMWZFYMV-UHFFFAOYSA-M
LogP-9.8
CAS DataBase Reference124-64-1(CAS DataBase Reference)
EPA Substance Registry SystemTetrakis(hydroxymethyl)phosphonium chloride (124-64-1)
Safety Information
Hazard Codes T,N
Risk Statements 21-25-38-41-42/43-51/53
Safety Statements 22-26-36/37/39-45-60-61-23
RIDADR UN 2810 6.1/PG 3
WGK Germany 3
RTECS TA2450000
HazardClass 8
PackingGroup III
HS Code 29319019
Hazardous Substances Data124-64-1(Hazardous Substances Data)
Toxicitymammal (species unspecified),LD50,oral,400mg/kg (400mg/kg),Kobunshi. High Polymers. Vol. 24, Pg. 788, 1975.
MSDS Information
Tetrakis(hydroxymethyl)phosphonium chloride Usage And Synthesis
Chemical PropertiesClear light pink or yellow-green solution
UsesFlame-retarding agent for cotton fabrics. May be used in combination with triethylolamine and urea (Roxel process) or with triethanolamine and tris(1-aziridinyl) phosphine oxide.
UsesTetrakis(hydroxymethyl)phosphonium chloride solution (80% in H2O) has been used as a reducing agent and stabilizing ligand for the synthesis of gold nanoparticles (AuNPs) from gold(III) chloride trihydrate (HAuCl4.3H2O). It is a tetra-functional, amine-reactive, aqueous crosslinker that can be used for tuning the properties of protein-based hydrogels for 3D cell encapsulation applications.
DefinitionA crystalline compound made by the reaction of phosphine, formaldehyde, and hydrochloric acid.
General DescriptionClear slightly viscous,colorless to yellow liquid (20% H2O solution).
Air & Water ReactionsHygroscopic. Water soluble.
Reactivity ProfileTetrakis(hydroxymethyl)phosphonium chloride reacts vigorously with oxidizers and alkalis. Reacts with cellulose.
Health HazardACUTE/CHRONIC HAZARDS: Tetrakis(hydroxymethyl)phosphonium chloride may be corrosive. When heated to decomposition, it may emit very toxic fumes of POx, hydrogen chloride and bis(chloromethyl)ether. Decomposition of Tetrakis(hydroxymethyl)phosphonium chloride in an aqueous environment may produce phosphine, formaldehyde and hydrogen chloride.
Fire HazardTetrakis(hydroxymethyl)phosphonium chloride is probably combustible.
Flammability and ExplosibilityNonflammable
Purification MethodsCrystallise it from AcOH and dry it at 100o in a vacuum. An 80% w/v aqueous solution has d4 1.33 [Reeves J Am Chem Soc 77 3923 1955]. [Beilstein 1 IV 3062.]
Tetrakis(hydroxymethyl)phosphonium chloride Preparation Products And Raw materials
Raw materialsFormaldehyde
Tetraisopropyl di(dioctylphosphate) titanate Tetrakis(hydroxymethyl)phosphonium sulfate Tetrakis(2-ethylhexanoic acid)titanium(IV) salt TETRAPHENYLPHOSPHONIUM TETRAPHENYLBORATE Thpc, Tetrakis[Hydroxymethyl] Phosphonium Chloride Tetrabutylphosphonium chloride Methyl trioctyl ammonium chloride TETRAPHENYLOLETHANE GLYCIDYL ETHER Tetrakis(hydroxymethyl)phosphonium chloride-carbamide DIMETHYLPHOSPHINOTHIOIC CHLORIDE Chlorodiphenylphosphine tetrakis(hydroxymethyl)phosphonium chloride urea polymer,tetrakis(Hydroxymethyl)phosphonium chloride-urea condensation product Thpc-Urea, Tetrakis[Hydroxymethyl] Phosphonium Chloride-Urea Amines, hydrogenated tallow alkyl, reaction products with tetrakis(hydroxymethyl)phosphonium chloride and urea Tris(hydroxymethyl)nitromethane Tetramethylol acetylenediurea Thionyl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile

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