NAFAMOSTAT MESYLATE

NAFAMOSTAT MESYLATE Basic information
Product Name:NAFAMOSTAT MESYLATE
Synonyms:6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE, MESYLATE;FUT-175;FUTHAN;NAFAMOSTAT MESILATE;NafamostatMesilateBase;6-Amidino-2-naphthyl 4-guanidinobenzoate;Nafamostat Dimethanesulfonate;Nafamstat
CAS:81525-10-2
MF:C19H17N5O2
MW:347.37
EINECS:1806241-263-5
Product Categories:
Mol File:81525-10-2.mol
NAFAMOSTAT MESYLATE Structure
NAFAMOSTAT MESYLATE Chemical Properties
Boiling point 586.0±60.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Soluble in DMSO
form Powder
pka11.30±0.30(Predicted)
Safety Information
MSDS Information
NAFAMOSTAT MESYLATE Usage And Synthesis
Chemical PropertiesOdorless, bitter taste. Easily soluble in water, insoluble in methanol, ethanol or dimethylformamide, almost insoluble in ether, chloroform or acetone. Density: 1.39g/cm3; Boiling Point: 637.2°C; Flash Point: 339.1°C; Vapor Pressure: 3.9E-16mmHg.
UsesNafamostat is a non-peptide synthetic protease inhibitor with broad-spectrum and potent enzyme inhibition. For the treatment of acute pancreatitis. It can improve acute symptoms of acute pancreatitis, acute exacerbation of chronic pancreatitis, and post-traumatic pancreatitis.
DefinitionChEBI: Nafamostat is a member of benzoic acids and a member of guanidines.
Preparation6-Bromo-2-naphthol reacts with copper cyanide in dimethylformamide to generate 6-cyano-2-naphthol, which is methanolylated and then aminolyzed to generate 6-amidino-2-naphthol , and finally esterification with p-guanidinobenzoic acid to generate nafamostat.
NAFAMOSTAT MESYLATE Preparation Products And Raw materials
Raw materials6-Bromo-2-naphthol-->6-Cyano-2-naphthol-->4-carbamimidamidobenzoic acid
Octreotide Acipimox Carteolol hydrochloride Pimecrolimus ULINASTATIN Leuprorelin Argatroban Tacrolimus NAFAMOSTAT MESYLATE 4-GUANIDINOBENZOIC ACID METHANESULFONATE 2-Naphthyl benzoate 6-AMIDINO-2-NAPHTHOL METHANESULFONATE Sepimostat N-P-TOLYL-GUANIDINE Nafamostat mesylate

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