|
| | Capecitabine Basic information |
| Product Name: | Capecitabine | | Synonyms: | N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine;Pentyl N-[1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-methyl-oxolan-2-yl]-5-fluoro-2-oxo-pyrimidin-4-yl]carbamate;Capiibine;Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester;Caxeta;Hsdb 7656;pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate | | CAS: | 158798-73-3 | | MF: | C15H22FN3O6 | | MW: | 359.35 | | EINECS: | | | Product Categories: | | | Mol File: | 158798-73-3.mol |  |
| | Capecitabine Chemical Properties |
| | Capecitabine Usage And Synthesis |
| Originator | Xeloda,Hoffmann - La
Roche Inc.,USA | | Manufacturing Process | 5-Deoxy-5-fluoro-N4-((n-pentyloxy)carbonyl)cytidine may be prepared
according to US Patent No. 6,114,520.
From 2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxy-5-fluorocytidine and n-pentylchloroformate in dichloromethane and pyridine may be obtained 2',3'-
bis-O-(tert-butyldimethylsilyl)-5'-deoxy-5-fluoro-N4-((pentyloxy)carbonyl)
cytidine.From 2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxy-5-fluoro-N4-
((pentyloxy)carbonyl)cytidineand tetrabutylammonium fluoride in
tetrahydrofuran at room temperature for 2 hours may be prepared the
product which by hydrolyses may be converted to 5-deoxy-5-fluoro-N4-
((pentyloxy)carbonyl)cytidine. Purification of the product may be carried out
by silica gel chromatography (using dichloromethane:methanol = 20:1 as an
eluent). | | Therapeutic Function | Antitumor |
| | Capecitabine Preparation Products And Raw materials |
|
