ChemicalBook Product Catalog Chemical Reagents Organic reagents Acyl halide Malonyl chloride

Malonyl chloride

Malonyl chloride Basic information
Product Name:Malonyl chloride
Synonyms:MALONYL CHLORIDE, STAB.;MALONYL DICHLORIDE 98+%;Malonyl dichloride, GC 97%;Prodipionyl Chloride;MALONYL CHLORIDE pract;Propanedioic acid dichloride;Malonyl dichloride,97%;Malonyl chloride,Malonyl dichloride
CAS:1663-67-8
MF:C3H2Cl2O2
MW:140.95
EINECS:216-772-9
Product Categories:Pyridines ,Halogenated Heterocycles;K00001
Mol File:1663-67-8.mol
Malonyl chloride Structure
Malonyl chloride Chemical Properties
Boiling point 53-55 °C/19 mmHg (lit.)
density 1.449 g/mL at 25 °C (lit.)
refractive index n20/D 1.465(lit.)
Fp 117 °F
storage temp. 2-8°C
pka6.86±0.46(Predicted)
form Liquid
color Clear yellow to orange to brown
Water Solubility decomposes
BRN 774044
CAS DataBase Reference1663-67-8(CAS DataBase Reference)
NIST Chemistry ReferenceMalonyl dichloride(1663-67-8)
EPA Substance Registry SystemPropanedioyl dichloride (1663-67-8)
Safety Information
Hazard Codes C
Risk Statements 14-34-29-10
Safety Statements 26-36/37/39-45-16
RIDADR UN 2920 8/PG 2
WGK Germany -
F 8-10
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29171990
MSDS Information
ProviderLanguage
Malonyl chloride English
SigmaAldrich English
ACROS English
Malonyl chloride Usage And Synthesis
Chemical Propertiesclear yellow to orange to brown liquid
UsesMalonyl chloride can be used as a reactant for the synthesis of:
  • Alkaloids with tetracyclic cores such as cyclopiamide A and speradine E.
  • 6-tetrathiafulvalene(TTF)-polymer by condensation polymerization with TTF-based dihydroxy monomer.
  • N-doped TiO2 films by molecular layer deposition.
  • Alkyne-substituted 1,3-oxazines by reaction with arylpropynamides.

It can also be used as a coupling agent in the synthesis of block copolymers by anionic polymerization.
UsesMalonyl Dichloride is primarily used an intermediate in the manufacture of pharmaceutical and agrochemical products.
Malonyl chloride Preparation Products And Raw materials
Preparation ProductsS,S'-Diethyldithiomalonate-->Diisopropyl malonate-->4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl--->4-Hydroxy-6-methyl-2-pyrone-->8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione-->1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER-->4-Hydroxypyran-2-one-->Diethyl malonyldicarbamate-->4-HYDROXY-6-METHYLCOUMARIN-->6,8-dichloropyrido[2,3-b]pyrazine-->Elesclomol-->DIOCTYL MALONATE
4-(Hydroxyamino)-4-oxobutanoic acid N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine Tofacitinib Impurity 29 CYANOACETIC ACID-OSU 1-Benzyl-4-methyl-piperidin-3-one hydrochloride methyl ((3R,4R)-4-methylpiperidin-3-yl)carbamate hydrochloride 6-AMINO-5(2,2-DIETHOXYETHYL)-4-HYDROXY-2-MERCAPTOPYRIMIDINE N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib Impurity 85 N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine BENZYL ETHYL ETHER 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE Methyl (4-Methylpiperidin-3-yl)carbaMate DIMETHYLMALONYL CHLORIDE MALONYL DICHLORIDE, (MALONYL CHLORIDE) DIETHYLMALONIC ACID DICHLORIDE 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile
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